DegronMD - Q8TBC3(SHKBP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R462C	TCGA-19-5956	GBM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.1389
p.N638S	TCGA-76-6282	GBM	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.1944
p.N495D	TCGA-AP-A1DR	UCEC	TCGA	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2778
p.G470S	TCGA-B0-5698	KIRC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.5882
p.A493T	TCGA-CG-4306	STAD	TCGA	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.2222
p.S466F	TCGA-D3-A8GL	SKCM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.25
p.S628T	TCGA-D5-6537	COAD	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.6005
p.S624L	TCGA-D8-A27G	BRCA	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation blocking phosphorylation signal	0.75
p.P499H	TCGA-EE-A2GH	SKCM	TCGA	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.7694
p.A475T	TCGA-EO-A22U	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6028
p.A475T	SIDM01619	Endometrial Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6028
p.A475T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6028
p.G490S	TCGA-HT-8018	LGG	TCGA	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1389
p.P621S	TCGA-RP-A694	SKCM	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.2222
p.I479M	TCGA-UC-A7PF	CESC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.25
p.D505N	TCGA-YD-A9TA	SKCM	TCGA	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.D505N	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.D505N	NCI-H520	lung	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.R632L	DO48566	BLCA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.8428
p.G465S	DO218159	BRCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2222
p.G465S	DO22645	LGG	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2222
p.R505W	DO4749	BRCA	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.R505W	DO22237	LGG	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.R505W	QGP-1	pancreas	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.R505W	HSC-39	stomach	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.R498H	DO8447	COAD	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.8244
p.R478W	DO227549	COCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2778
p.R498C	DO233624	GACA	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.8301
p.R498C	SNU-175	large intestine	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.8301
p.Q494K	DO20872	KIRP	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.25
p.G469C	DO228952	LICA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.76
p.G621W	DO229008	LICA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.2222
p.V509L	DO52311	LIHC	ICGC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1389
p.A460G	DO23174	LINC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.0833
p.P474S	DO220902	MELA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6752
p.S615F	DO222875	MELA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.0556
p.R641H	DO222837	MELA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.1111
p.P474H	DO37643	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.7694
p.D480N	DO219503	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2222
p.D480N	NCI-H520	lung	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2222
p.A468T	DO38567	STAD	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.3056
p.R632C	DO41235	UCEC	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.8301
p.N470D	DO43747	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6932
p.P615H	SIDM00557	Neuroblastoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.0556
p.L620V	SIDM00995	Other Solid Cancers	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.1944
p.L620V	ACH-001328	Skin Cancer	CCLE	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.1944
p.L620V	A431	skin	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.1944
p.S492N	SIDM00247	Gastric Carcinoma	GDSC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1944
p.S492N	ACH-000356	Gastric Cancer	CCLE	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1944
p.S492N	MKN45	stomach	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1944
p.G470A	SIDM00097	Breast Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6429
p.G470A	ACH-000147	Breast Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6429
p.G470A	T47D	breast	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6429
p.S628Y	SIDM00793	Burkitt's Lymphoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.6009
p.S628Y	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.6009
p.R460L	SIDM00685	Glioblastoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.0833
p.R460L	ACH-000819	Brain Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.0833
p.R460L	LN-18	central nervous system	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.0833
p.G463S	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.1667
p.G463S	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.1667
p.G463S	SNU-1040	large intestine	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.1667
p.S471F	SIDM00867	Glioblastoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6871
p.S471F	ACH-000863	Brain Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6871
p.S471F	DBTRG-05MG	central nervous system	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation altering degron motif	0.6871
p.S634L	ACH-000829	Myeloma	CCLE	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation rewiring degron network	0.3056
p.V497M	639-V	urinary tract	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation altering degron motif	0.7208
p.S467N	MKN45	stomach	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	469:476	Mutation rewiring degron network	0.2778
p.R631Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.7329
p.C507R	HCT-116	large intestine	COSMIC	IGPYGE	LIG_APCC_ABBA_1	497:502	Mutation rewiring degron network	0.1944
p.R633C	MDA-MB-231	breast	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	625:633	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHKBP1

UniProt ID: Q8TBC3

Entrez ID: 92799

Protein name: SH3KBP1-binding protein 1 (SETA-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHKBP1 in