DegronMD

Uniprot ID: Q8TBC3

Source protein: SH3KBP1-binding protein 1

Source gene: SHKBP1

Class: DEG_APCC_DBOX_1

Location: 625:633

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9645

ASA_SCORE: 74.0778

COIL: 0.771

CONS_SCORE: 0.3771

DSS_SCORE: 0.5435

HELIX: 0.1363

FCONS_SCORE: 0.9419

RIG_SCORE: 0.6327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N638S	TCGA-76-6282	GBM	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	0.1944
p.S628T	TCGA-D5-6537	COAD	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	0.6005
p.S624L	TCGA-D8-A27G	BRCA	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	0.75
p.P621S	TCGA-RP-A694	SKCM	TCGA	PRISLTSLH	DEG_APCC_DBOX_1	0.2222
p.R632L	DO48566	BLCA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	0.8428
p.G621W	DO229008	LICA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	0.2222
p.S615F	DO222875	MELA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	0.0556
p.R641H	DO222837	MELA	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	0.1111
p.R632C	DO41235	UCEC	ICGC	PRISLTSLH	DEG_APCC_DBOX_1	0.8301
p.P615H	SIDM00557	Neuroblastoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	0.0556
p.L620V	SIDM00995	Other Solid Cancers	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	0.1944
p.L620V	ACH-001328	Skin Cancer	CCLE	PRISLTSLH	DEG_APCC_DBOX_1	0.1944
p.L620V	A431	skin	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	0.1944
p.S628Y	SIDM00793	Burkitt's Lymphoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	0.6009
p.S628Y	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PRISLTSLH	DEG_APCC_DBOX_1	0.6009
p.S634L	ACH-000829	Myeloma	CCLE	PRISLTSLH	DEG_APCC_DBOX_1	0.3056
p.R631Q	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	0.7329
p.R633C	MDA-MB-231	breast	COSMIC	PRISLTSLH	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBC3	SH3KBP1-binding protein 1	DEG_APCC_DBOX_1	625:633	PRISLTSLH	APC,CDC20,FZR1	0.9645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons