DegronMD

Uniprot ID: Q8TBC3

Source protein: SH3KBP1-binding protein 1

Source gene: SHKBP1

Class: DEG_SCF_FBW7_1

Location: 469:476

E3 ligase: FBXW7

DEGRON score: 0.5017

ASA_SCORE: 52

COIL: 0.6466

CONS_SCORE: 0.8335

DSS_SCORE: 0.3358

HELIX: 0.0399

FCONS_SCORE: 1.1268

RIG_SCORE: 0.7507

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P474H	DO37643	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.7694
p.G469C	DO228952	LICA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.76
p.N470D	DO43747	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.6932
p.S471F	SIDM00867	Glioblastoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	0.6871
p.S471F	ACH-000863	Brain Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	0.6871
p.S471F	DBTRG-05MG	central_nervous_system	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	0.6871
p.P474S	DO220902	MELA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.6752
p.G470A	SIDM00097	Breast Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	0.6429
p.G470A	ACH-000147	Breast Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	0.6429
p.G470A	T47D	breast	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	0.6429
p.A475T	TCGA-EO-A22U	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.6028
p.A475T	SIDM01619	Endometrial Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	0.6028
p.A475T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	0.6028
p.G470S	TCGA-B0-5698	KIRC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.5882
p.A468T	DO38567	STAD	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.3056
p.R478W	DO227549	COCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.S467N	MKN45	stomach	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.S466F	TCGA-D3-A8GL	SKCM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.25
p.I479M	TCGA-UC-A7PF	CESC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.25
p.G465S	DO218159	BRCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2222
p.G465S	DO22645	LGG	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2222
p.D480N	DO219503	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2222
p.D480N	NCI-H520	lung	COSMIC	PGSTPLAS	DEG_SCF_FBW7_1	0.2222
p.G463S	SIDM00217	Colorectal Carcinoma	GDSC	PGSTPLAS	DEG_SCF_FBW7_1	0.1667
p.G463S	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSTPLAS	DEG_SCF_FBW7_1	0.1667

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Drug responses associated with SHKBP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGSTPLAS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y597	BTB/POZ domain-containing protein KCTD3	DEG_SCF_FBW7_1	460:467	PGSTPLAS	FBXW7	0.9943	More...
Q8TBC3	SH3KBP1-binding protein 1	DEG_SCF_FBW7_1	469:476	PGSTPLAS	FBXW7	0.5017	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTPLAS

Degron related mutations and impact score

Drug responses associated with SHKBP1 mutations

All proteins holding degron of PGSTPLAS