DegronMD

Uniprot ID: Q9Y597

Source protein: BTB/POZ domain-containing protein KCTD3

Source gene: KCTD3

Class: DEG_SCF_FBW7_1

Location: 460:467

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 57.9125

COIL: 0.7245

CONS_SCORE: 0.8534

DSS_SCORE: 0.3927

HELIX: 0.0431

FCONS_SCORE: 1.1008

RIG_SCORE: 0.7409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K469N	TCGA-06-5416	GBM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.K469N	TCGA-EO-A22X	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.K469N	DO10880	GBM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.K469N	DO43907	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.2778
p.R451Q	TCGA-AX-A1CE	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.0833
p.R451Q	DO42280	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.0833
p.S462C	TCGA-BH-A0DK	BRCA	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.643
p.S462C	DO1305	BRCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.643
p.S462P	TCGA-DI-A1BU	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.5641
p.S462P	DO42023	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.5641
p.P464S	TCGA-ER-A2NH	SKCM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.6752
p.P464S	DO47683	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.6752
p.A466V	TCGA-IP-7968	STAD	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.5825
p.A466V	DO38183	STAD	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.5825
p.S462F	TCGA-KQ-A41R	BLCA	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	0.6871
p.S462F	DO223592	BLCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBC3	SH3KBP1-binding protein 1	DEG_SCF_FBW7_1	469:476	PGSTPLAS	FBXW7	0.5017	More...
Q9Y597	BTB/POZ domain-containing protein KCTD3	DEG_SCF_FBW7_1	460:467	PGSTPLAS	FBXW7	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons