DegronMD - Q9Y597(KCTD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K469N	TCGA-06-5416	GBM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.2778
p.K469N	TCGA-EO-A22X	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.2778
p.K469N	DO10880	GBM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.2778
p.K469N	DO43907	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.2778
p.P654S	TCGA-17-Z049	LUAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.2778
p.R658S	TCGA-91-6829	LUAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1667
p.R658S	DO23564	LUAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1667
p.T637I	TCGA-AA-A022	COAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.0556
p.T637I	DO10647	COAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.0556
p.R451Q	TCGA-AX-A1CE	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.0833
p.R451Q	DO42280	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation rewiring degron network	0.0833
p.S462C	TCGA-BH-A0DK	BRCA	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.643
p.S462C	DO1305	BRCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.643
p.T643I	TCGA-BR-A4IY	STAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.2222
p.T643I	DO38396	STAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.2222
p.E640G	TCGA-CM-6680	COAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1389
p.E640G	DO9772	COAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1389
p.R658M	TCGA-D3-A2JB	SKCM	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1667
p.R658M	DO47607	SKCM	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1667
p.S462P	TCGA-DI-A1BU	UCEC	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.5641
p.S462P	DO42023	UCEC	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.5641
p.P654H	TCGA-EO-A3B0	UCEC	TCGA	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.2778
p.P654H	DO219773	UCEC	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.2778
p.P464S	TCGA-ER-A2NH	SKCM	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.6752
p.P464S	DO47683	SKCM	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.6752
p.A466V	TCGA-IP-7968	STAD	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.5825
p.A466V	DO38183	STAD	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.5825
p.S462F	TCGA-KQ-A41R	BLCA	TCGA	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.6871
p.S462F	DO223592	BLCA	ICGC	PGSTPLAS	DEG_SCF_FBW7_1	460:467	Mutation altering degron motif	0.6871
p.H639D	DO50872	LICA	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation rewiring degron network	0.1111
p.S653G	DO231813	LINC	ICGC	MRPYRE	LIG_APCC_ABBA_1	647:652	Mutation blocking phosphorylation signal	0.75

Kaplan plot for KCTD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCTD3

UniProt ID: Q9Y597

Entrez ID: 51133

Protein name: BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCTD3 in