DegronMD

Uniprot ID: Q9Y597

Source protein: BTB/POZ domain-containing protein KCTD3

Source gene: KCTD3

Class: LIG_APCC_ABBA_1

Location: 647:652

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9768

ASA_SCORE: 106.05

COIL: 0.8692

CONS_SCORE: 0.4052

DSS_SCORE: 0.499

HELIX: 0.0733

FCONS_SCORE: 1.0191

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P654S	TCGA-17-Z049	LUAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.2778
p.R658S	TCGA-91-6829	LUAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.1667
p.R658S	DO23564	LUAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.1667
p.T637I	TCGA-AA-A022	COAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.0556
p.T637I	DO10647	COAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.0556
p.T643I	TCGA-BR-A4IY	STAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.2222
p.T643I	DO38396	STAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.2222
p.E640G	TCGA-CM-6680	COAD	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.1389
p.E640G	DO9772	COAD	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.1389
p.R658M	TCGA-D3-A2JB	SKCM	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.1667
p.R658M	DO47607	SKCM	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.1667
p.P654H	TCGA-EO-A3B0	UCEC	TCGA	MRPYRE	LIG_APCC_ABBA_1	0.2778
p.P654H	DO219773	UCEC	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.2778
p.H639D	DO50872	LICA	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.1111
p.S653G	DO231813	LINC	ICGC	MRPYRE	LIG_APCC_ABBA_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y597	BTB/POZ domain-containing protein KCTD3	LIG_APCC_ABBA_1	647:652	MRPYRE	APC,CDC20,FZR1	0.9768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons