DegronMD

Uniprot ID: Q96RT8

Source protein: Gamma-tubulin complex component 5

Source gene: TUBGCP5

Class: LIG_APCC_ABBA_1

Location: 155:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9667

ASA_SCORE: 72.4333

COIL: 0.8728

CONS_SCORE: 0.4363

DSS_SCORE: 0.6811

HELIX: 0.094

FCONS_SCORE: 0.9994

RIG_SCORE: 0.6961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P157L	TCGA-EO-A22R	UCEC	TCGA	IGPYMD	LIG_APCC_ABBA_1	0.6471
p.P157L	DO222396	MELA	ICGC	IGPYMD	LIG_APCC_ABBA_1	0.6471
p.P157L	DO42713	UCEC	ICGC	IGPYMD	LIG_APCC_ABBA_1	0.6471
p.P157L	SIDM01951	Colorectal Carcinoma	GDSC	IGPYMD	LIG_APCC_ABBA_1	0.6471
p.L147F	DO1160	BRCA	ICGC	IGPYMD	LIG_APCC_ABBA_1	0.1111
p.P157Q	DO227549	COCA	ICGC	IGPYMD	LIG_APCC_ABBA_1	0.7035
p.Y158C	SIDM00924	Other Solid Cancers	GDSC	IGPYMD	LIG_APCC_ABBA_1	0.7087
p.Y158C	ACH-000867	Lung Cancer	CCLE	IGPYMD	LIG_APCC_ABBA_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT8	Gamma-tubulin complex component 5	LIG_APCC_ABBA_1	155:160	IGPYMD	APC,CDC20,FZR1	0.9667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons