DegronMD - Q96RT8(TUBGCP5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P157L	TCGA-EO-A22R	UCEC	TCGA	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.P157L	DO222396	MELA	ICGC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.P157L	DO42713	UCEC	ICGC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.P157L	SIDM01951	Colorectal Carcinoma	GDSC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.6471
p.D173Y	TCGA-KQ-A41N	BLCA	TCGA	MDTPNWS	DEG_SCF_FBW7_1	159:165	Mutation rewiring degron network	0.1111
p.D173Y	DO223588	BLCA	ICGC	MDTPNWS	DEG_SCF_FBW7_1	159:165	Mutation rewiring degron network	0.1111
p.L147F	DO1160	BRCA	ICGC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation rewiring degron network	0.1111
p.P157Q	DO227549	COCA	ICGC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.7035
p.D173V	DO228151	PBCA	ICGC	MDTPNWS	DEG_SCF_FBW7_1	159:165	Mutation rewiring degron network	0.1111
p.Y158C	SIDM00924	Other Solid Cancers	GDSC	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.7087
p.Y158C	ACH-000867	Lung Cancer	CCLE	IGPYMD	LIG_APCC_ABBA_1	155:160	Mutation altering degron motif	0.7087

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons