DegronMD

Uniprot ID: Q96R06

Source protein: Sperm-associated antigen 5

Source gene: SPAG5

Class: DEG_SCF_FBW7_1

Location: 374:381

E3 ligase: FBXW7

DEGRON score: 0.9883

ASA_SCORE: 75.8625

COIL: 0.8334

CONS_SCORE: 0.7773

DSS_SCORE: 0.2917

HELIX: 0.041

FCONS_SCORE: 0.9634

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T376N	TCGA-A5-A0G2	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.7055
p.T376N	DO41235	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.7055
p.D371N	TCGA-A5-A0G2	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.D371N	DO41235	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.A372D	TCGA-AP-A051	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.2778
p.A372D	DO42673	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.2778
p.D371E	TCGA-AP-A054	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.D371E	DO42256	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.S364F	TCGA-D1-A17Q	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.5
p.S364F	DO41903	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.5
p.D371Y	TCGA-DD-AAEI	LIHC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.D371Y	DO219575	LIHC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.25
p.S367L	TCGA-DK-A6B6	BLCA	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.5833
p.S367L	DO48576	BLCA	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.5833
p.S391L	TCGA-EK-A2R8	CESC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.0556
p.S391L	DO51599	CESC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.0556
p.P390H	TCGA-FR-A8YC	SKCM	TCGA	IGTTPFST	DEG_SCF_FBW7_1	0.0833
p.P390H	DO50301	SKCM	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.0833
p.R370Q	DO223044	ESCA	ICGC	IGTTPFST	DEG_SCF_FBW7_1	0.2222
p.T377A	SIDM02049	Pancreatic Carcinoma	GDSC	IGTTPFST	DEG_SCF_FBW7_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96R06	Sperm-associated antigen 5	DEG_SCF_FBW7_1	374:381	IGTTPFST	FBXW7	0.9883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons