DegronMD - Q96R06(SPAG5)

FUNCTION: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole archite... View more >>

GO - Biological processes (BP): cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of intracellular transport [GO:0032388]; positive regulation of spindle assembly [GO:1905832]; protein localization to centrosome [GO:0071539]; regulation of attach... View more >>

GO - Molecular function (MF): microtubule binding [GO:0008017]

GO - Cellular component (CC): centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule plus-end [GO:0035371]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T377A	SIDM02049	Pancreatic Carcinoma	GDSC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.825
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8102
p.R23I	DO7801	COAD	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8102
p.P25L	TCGA-85-8049	LUSC	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7582
p.P25L	DO26890	LUSC	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7582
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking phosphorylation signal	0.75
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking phosphorylation signal	0.75
p.M22T	DO227976	COCA	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7423
p.T376N	TCGA-A5-A0G2	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.7055
p.T376N	DO41235	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.7055
p.P964Q	TCGA-CD-A4MG	STAD	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.7035
p.P964Q	DO48009	STAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.7035
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.6991
p.R23I	DO7801	COAD	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.6991
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944
p.K19N	SNU-1040	large intestine	COSMIC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	SNU-1040	large intestine	COSMIC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944

Showing 1 to 20 of 86 entries

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Kaplan plot for SPAG5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG5

UniProt ID: Q96R06

Entrez ID: 10615

Protein name: Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG5 in