DegronMD - Q96R06(SPAG5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P25L	TCGA-85-8049	LUSC	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6471
p.P25L	TCGA-85-8049	LUSC	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7582
p.P25L	DO26890	LUSC	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6471
p.P25L	DO26890	LUSC	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7582
p.T376N	TCGA-A5-A0G2	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.7055
p.T376N	DO41235	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.7055
p.D371N	TCGA-A5-A0G2	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.D371N	DO41235	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.E972D	TCGA-A5-A2K5	UCEC	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1944
p.E972D	DO41379	UCEC	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1944
p.I105V	TCGA-A8-A09B	BRCA	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.25
p.I105V	DO1653	BRCA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.25
p.T950I	TCGA-AD-A5EJ	COAD	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation blocking phosphorylation signal	0.5
p.T950I	DO50090	COAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation blocking phosphorylation signal	0.5
p.A372D	TCGA-AP-A051	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2778
p.A372D	DO42673	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2778
p.D371E	TCGA-AP-A054	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.D371E	DO42256	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.N124D	TCGA-CA-6717	COAD	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.0833
p.N124D	DO8264	COAD	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.0833
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8102
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.6991
p.R23I	DO7801	COAD	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8102
p.R23I	DO7801	COAD	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.6991
p.P964Q	TCGA-CD-A4MG	STAD	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.7035
p.P964Q	DO48009	STAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.7035
p.M973I	TCGA-CV-5432	HNSC	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1667
p.M973I	DO14343	HNSC	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1667
p.S364F	TCGA-D1-A17Q	UCEC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation blocking phosphorylation signal	0.5
p.S364F	DO41903	UCEC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation blocking phosphorylation signal	0.5
p.D371Y	TCGA-DD-AAEI	LIHC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.D371Y	DO219575	LIHC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.25
p.S367L	TCGA-DK-A6B6	BLCA	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation blocking phosphorylation signal	0.5833
p.S367L	DO48576	BLCA	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation blocking phosphorylation signal	0.5833
p.Y125F	TCGA-E2-A14T	BRCA	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation blocking phosphorylation signal	0.5
p.Y125F	DO5109	BRCA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation blocking phosphorylation signal	0.5
p.P106L	TCGA-EE-A29D	SKCM	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.2778
p.P106L	DO38123	SKCM	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.2778
p.S391L	TCGA-EK-A2R8	CESC	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.0556
p.S391L	DO51599	CESC	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.0556
p.S110C	TCGA-EK-A2R8	CESC	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.643
p.S110C	DO51599	CESC	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.643
p.P390H	TCGA-FR-A8YC	SKCM	TCGA	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.0833
p.P390H	DO50301	SKCM	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.0833
p.G18R	TCGA-GN-A4U7	SKCM	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.G18R	TCGA-GN-A4U7	SKCM	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.2222
p.G18R	DO51258	SKCM	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.G18R	DO51258	SKCM	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.2222
p.R951P	TCGA-V9-A7HT	KIRP	TCGA	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.0833
p.R951P	DO219717	KIRP	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.0833
p.L36F	TCGA-XF-A9T0	BLCA	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1667
p.L36F	TCGA-XF-A9T0	BLCA	TCGA	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.1111
p.L36F	DO51920	BLCA	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1667
p.L36F	DO51920	BLCA	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.1111
p.M22T	DO227976	COCA	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6312
p.M22T	DO227976	COCA	ICGC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation altering degron motif	0.7423
p.M955K	DO50370	ESAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1944
p.R370Q	DO223044	ESCA	ICGC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation rewiring degron network	0.2222
p.P964S	DO233709	GACA	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.6752
p.L122M	DO228974	LICA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.1389
p.P104T	DO228976	LICA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.2222
p.A953S	DO232224	PBCA	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1389
p.E962D	DO232224	PBCA	ICGC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.5647
p.T377A	SIDM02049	Pancreatic Carcinoma	GDSC	IGTTPFST	DEG_SCF_FBW7_1	374:381	Mutation altering degron motif	0.825
p.R951Q	SIDM02077	Colorectal Carcinoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.0833
p.N38S	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.N38S	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.0556
p.N38S	ACH-000414	Lung Cancer	CCLE	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.N38S	ACH-000414	Lung Cancer	CCLE	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.0556
p.N38S	NCI-H1944	lung	COSMIC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1111
p.N38S	NCI-H1944	lung	COSMIC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation rewiring degron network	0.0556
p.M955V	SIDM00525	Osteosarcoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation rewiring degron network	0.1944
p.K113T	SIDM00465	Ovarian Carcinoma	GDSC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.6195
p.K113T	ACH-002183	Ovarian Cancer	CCLE	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.6195
p.K113T	OVMIU	ovary	COSMIC	ISSTPKTS	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.6195
p.P960L	SIDM00254	Neuroblastoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.6471
p.P960L	ACH-002283	Neuroblastoma	CCLE	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.6471
p.P960L	NB5	autonomic ganglia	COSMIC	PAETPGME	DEG_SCF_FBW7_2	960:967	Mutation altering degron motif	0.6471
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944
p.K19N	SNU-1040	large intestine	COSMIC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking ubiquitination signal	0.6944
p.K19N	SNU-1040	large intestine	COSMIC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking ubiquitination signal	0.6944
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	22:30	Mutation blocking phosphorylation signal	0.75
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	22:28	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG5

UniProt ID: Q96R06

Entrez ID: 10615

Protein name: Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG5 in