DegronMD

Uniprot ID: Q96R06

Source protein: Sperm-associated antigen 5

Source gene: SPAG5

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9869

ASA_SCORE: 85.5778

COIL: 0.6312

CONS_SCORE: 0.9029

DSS_SCORE: 0.6727

HELIX: 0.1847

FCONS_SCORE: 1.0759

RIG_SCORE: 0.7251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P25L	TCGA-85-8049	LUSC	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	0.6471
p.P25L	DO26890	LUSC	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	0.6471
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	0.8102
p.R23I	DO7801	COAD	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	0.8102
p.G18R	TCGA-GN-A4U7	SKCM	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	0.2222
p.G18R	DO51258	SKCM	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	0.2222
p.L36F	TCGA-XF-A9T0	BLCA	TCGA	MRTPLRELT	DEG_APCC_DBOX_1	0.1667
p.L36F	DO51920	BLCA	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	0.1667
p.M22T	DO227976	COCA	ICGC	MRTPLRELT	DEG_APCC_DBOX_1	0.6312
p.N38S	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	0.1111
p.N38S	ACH-000414	Lung Cancer	CCLE	MRTPLRELT	DEG_APCC_DBOX_1	0.1111
p.N38S	NCI-H1944	lung	COSMIC	MRTPLRELT	DEG_APCC_DBOX_1	0.1111
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRELT	DEG_APCC_DBOX_1	0.6944
p.K19N	SNU-1040	large_intestine	COSMIC	MRTPLRELT	DEG_APCC_DBOX_1	0.6944
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRELT	DEG_APCC_DBOX_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96R06	Sperm-associated antigen 5	DEG_APCC_DBOX_1	22:30	MRTPLRELT	APC,CDC20,FZR1	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons