DegronMD

Uniprot ID: Q96R06

Source protein: Sperm-associated antigen 5

Source gene: SPAG5

Class: DEG_SCF_FBW7_1

Location: 108:115

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 75.7375

COIL: 0.9038

CONS_SCORE: 0.6459

DSS_SCORE: 0.6451

HELIX: 0.0525

FCONS_SCORE: 1.0457

RIG_SCORE: 0.6464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I105V	TCGA-A8-A09B	BRCA	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	0.25
p.I105V	DO1653	BRCA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.25
p.N124D	TCGA-CA-6717	COAD	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	0.0833
p.N124D	DO8264	COAD	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.0833
p.Y125F	TCGA-E2-A14T	BRCA	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	0.5
p.Y125F	DO5109	BRCA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.5
p.P106L	TCGA-EE-A29D	SKCM	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	0.2778
p.P106L	DO38123	SKCM	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.2778
p.S110C	TCGA-EK-A2R8	CESC	TCGA	ISSTPKTS	DEG_SCF_FBW7_1	0.643
p.S110C	DO51599	CESC	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.643
p.L122M	DO228974	LICA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.1389
p.P104T	DO228976	LICA	ICGC	ISSTPKTS	DEG_SCF_FBW7_1	0.2222
p.K113T	SIDM00465	Ovarian Carcinoma	GDSC	ISSTPKTS	DEG_SCF_FBW7_1	0.6195
p.K113T	ACH-002183	Ovarian Cancer	CCLE	ISSTPKTS	DEG_SCF_FBW7_1	0.6195
p.K113T	OVMIU	ovary	COSMIC	ISSTPKTS	DEG_SCF_FBW7_1	0.6195

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96R06	Sperm-associated antigen 5	DEG_SCF_FBW7_1	108:115	ISSTPKTS	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons