DegronMD

Uniprot ID: Q96R06

Source protein: Sperm-associated antigen 5

Source gene: SPAG5

Class: DEG_SCF_FBW7_2

Location: 960:967

E3 ligase: FBXW7

DEGRON score: 0.9065

ASA_SCORE: 96.7875

COIL: 0.5214

CONS_SCORE: 0.6262

DSS_SCORE: 0.5207

HELIX: 0.4745

FCONS_SCORE: 1.0145

RIG_SCORE: 0.6906

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E972D	TCGA-A5-A2K5	UCEC	TCGA	PAETPGME	DEG_SCF_FBW7_2	0.1944
p.E972D	DO41379	UCEC	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.1944
p.T950I	TCGA-AD-A5EJ	COAD	TCGA	PAETPGME	DEG_SCF_FBW7_2	0.5
p.T950I	DO50090	COAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.5
p.P964Q	TCGA-CD-A4MG	STAD	TCGA	PAETPGME	DEG_SCF_FBW7_2	0.7035
p.P964Q	DO48009	STAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.7035
p.M973I	TCGA-CV-5432	HNSC	TCGA	PAETPGME	DEG_SCF_FBW7_2	0.1667
p.M973I	DO14343	HNSC	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.1667
p.R951P	TCGA-V9-A7HT	KIRP	TCGA	PAETPGME	DEG_SCF_FBW7_2	0.0833
p.R951P	DO219717	KIRP	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.0833
p.M955K	DO50370	ESAD	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.1944
p.P964S	DO233709	GACA	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.6752
p.A953S	DO232224	PBCA	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.1389
p.E962D	DO232224	PBCA	ICGC	PAETPGME	DEG_SCF_FBW7_2	0.5647
p.R951Q	SIDM02077	Colorectal Carcinoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	0.0833
p.M955V	SIDM00525	Osteosarcoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	0.1944
p.P960L	SIDM00254	Neuroblastoma	GDSC	PAETPGME	DEG_SCF_FBW7_2	0.6471
p.P960L	ACH-002283	Neuroblastoma	CCLE	PAETPGME	DEG_SCF_FBW7_2	0.6471
p.P960L	NB5	autonomic_ganglia	COSMIC	PAETPGME	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96R06	Sperm-associated antigen 5	DEG_SCF_FBW7_2	960:967	PAETPGME	FBXW7	0.9065	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons