DegronMD

Uniprot ID: Q96R06

Source protein: Sperm-associated antigen 5

Source gene: SPAG5

Class: DEG_SCF_FBW7_2

Location: 22:28

E3 ligase: FBXW7

DEGRON score: 0.9846

ASA_SCORE: 92.5286

COIL: 0.6479

CONS_SCORE: 0.9417

DSS_SCORE: 0.6861

HELIX: 0.2016

FCONS_SCORE: 1.1357

RIG_SCORE: 0.7173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P25L	TCGA-85-8049	LUSC	TCGA	MRTPLRE	DEG_SCF_FBW7_2	0.7582
p.P25L	DO26890	LUSC	ICGC	MRTPLRE	DEG_SCF_FBW7_2	0.7582
p.R23I	TCGA-CA-6718	COAD	TCGA	MRTPLRE	DEG_SCF_FBW7_2	0.6991
p.R23I	DO7801	COAD	ICGC	MRTPLRE	DEG_SCF_FBW7_2	0.6991
p.G18R	TCGA-GN-A4U7	SKCM	TCGA	MRTPLRE	DEG_SCF_FBW7_2	0.2222
p.G18R	DO51258	SKCM	ICGC	MRTPLRE	DEG_SCF_FBW7_2	0.2222
p.L36F	TCGA-XF-A9T0	BLCA	TCGA	MRTPLRE	DEG_SCF_FBW7_2	0.1111
p.L36F	DO51920	BLCA	ICGC	MRTPLRE	DEG_SCF_FBW7_2	0.1111
p.M22T	DO227976	COCA	ICGC	MRTPLRE	DEG_SCF_FBW7_2	0.7423
p.N38S	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	0.0556
p.N38S	ACH-000414	Lung Cancer	CCLE	MRTPLRE	DEG_SCF_FBW7_2	0.0556
p.N38S	NCI-H1944	lung	COSMIC	MRTPLRE	DEG_SCF_FBW7_2	0.0556
p.K19N	SIDM00217	Colorectal Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	0.6944
p.K19N	ACH-000999	Colon/Colorectal Cancer	CCLE	MRTPLRE	DEG_SCF_FBW7_2	0.6944
p.K19N	SNU-1040	large_intestine	COSMIC	MRTPLRE	DEG_SCF_FBW7_2	0.6944
p.S21Y	SIDM01609	Endometrial Carcinoma	GDSC	MRTPLRE	DEG_SCF_FBW7_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96R06	Sperm-associated antigen 5	DEG_SCF_FBW7_2	22:28	MRTPLRE	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons