DegronMD

Uniprot ID: Q6UX41

Source protein: Butyrophilin-like protein 8

Source gene: BTNL8

Class: LIG_APCC_ABBA_1

Location: 407:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5054

ASA_SCORE: 8.4667

COIL: 0.0335

CONS_SCORE: 0.7215

DSS_SCORE: 0.0651

HELIX: 0.003

FCONS_SCORE: 1.5047

RIG_SCORE: 0.9307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V398I	TCGA-12-1092	GBM	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.0833
p.V398I	TCGA-E2-A15O	BRCA	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.0833
p.V398I	TCGA-EY-A215	UCEC	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.0833
p.C415S	TCGA-35-4122	LUAD	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.25
p.F421I	TCGA-55-8092	LUAD	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.0833
p.P400S	TCGA-D3-A8GI	SKCM	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.1389
p.P400S	TCGA-EE-A2MS	SKCM	TCGA	IGVFLD	LIG_APCC_ABBA_1	0.1389
p.C415G	SIDM00863	Burkitt's Lymphoma	GDSC	IGVFLD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX41	Butyrophilin-like protein 8	LIG_APCC_ABBA_1	407:412	IGVFLD	APC,CDC20,FZR1	0.5054	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons