DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IHIFNE
Uniprot ID:
P19823
Source protein:
Inter-alpha-trypsin inhibitor heavy chain H2
Source gene:
ITIH2
Class:
LIG_APCC_ABBA_1
Location:
869:874
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5336
ASA_SCORE:
60.1833
COIL:
0.3728
CONS_SCORE:
0.293
DSS_SCORE:
0.638
HELIX:
0.0527
FCONS_SCORE:
0.8406
RIG_SCORE:
0.7554
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E884K
TCGA-90-A4ED
LUSC
TCGA
IHIFNE
LIG_APCC_ABBA_1
0.0556
p.P880H
TCGA-BR-6566
STAD
TCGA
IHIFNE
LIG_APCC_ABBA_1
0.1667
p.G877E
TCGA-EE-A2GO
SKCM
TCGA
IHIFNE
LIG_APCC_ABBA_1
0.25
p.K878N
TCGA-ER-A19N
SKCM
TCGA
IHIFNE
LIG_APCC_ABBA_1
0.3333
p.E877A
DO11567
GBM
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.25
p.G880W
DO26466
LUSC
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.1667
p.E873K
DO45482
LUSC
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.7022
p.G866E
DO37823
SKCM
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.25
p.K867N
DO37452
SKCM
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.2778
p.P869H
DO38217
STAD
ICGC
IHIFNE
LIG_APCC_ABBA_1
0.7694
p.I871V
SIDM00773
Non-Cancerous
GDSC
IHIFNE
LIG_APCC_ABBA_1
0.5965
p.I871V
SIDM00774
Breast Carcinoma
GDSC
IHIFNE
LIG_APCC_ABBA_1
0.5965
Drug responses associated with ITIH2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IHIFNE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P19823
Inter-alpha-trypsin inhibitor heavy chain H2
LIG_APCC_ABBA_1
869:874
IHIFNE
APC,CDC20,FZR1
0.5336
More...