DegronMD - P19823(ITIH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S616Y	TCGA-05-5425	LUAD	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1944
p.W669R	TCGA-50-5930	LUAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.25
p.L625M	TCGA-55-8616	LUAD	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.5999
p.E884K	TCGA-90-A4ED	LUSC	TCGA	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.0556
p.E884K	TCGA-90-A4ED	LUSC	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.0556
p.Q614R	TCGA-A5-A0VQ	UCEC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1389
p.S611L	TCGA-B5-A3FA	UCEC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.0556
p.P880H	TCGA-BR-6566	STAD	TCGA	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.1667
p.P880H	TCGA-BR-6566	STAD	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.1667
p.I678V	TCGA-CH-5767	PRAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation altering degron motif	0.5965
p.D636N	TCGA-CV-7568	HNSC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.0833
p.G858R	TCGA-EE-A29M	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.0556
p.G877E	TCGA-EE-A2GO	SKCM	TCGA	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.25
p.G877E	TCGA-EE-A2GO	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.25
p.K878N	TCGA-ER-A19N	SKCM	TCGA	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation substituting flanking lysine	0.3333
p.K878N	TCGA-ER-A19N	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation substituting flanking lysine	0.3333
p.P667L	TCGA-FC-A8O0	PRAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1944
p.Q686E	TCGA-VS-A8EL	CESC	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1389
p.G684E	TCGA-W3-AA1W	SKCM	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1944
p.E633K	TCGA-Z2-A8RT	SKCM	TCGA	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1667
p.V666M	DO48424	BLCA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1667
p.S616L	DO218173	BRCA	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1944
p.S616L	ACH-000560	Gastric Cancer	CCLE	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1944
p.S616L	ECC10	stomach	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1944
p.T680M	DO222486	BTCA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.3056
p.Q675E	DO51624	CESC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation altering degron motif	0.6744
p.M628V	DO8826	COAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.3056
p.Q635H	DO227984	COCA	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1111
p.E620G	DO50406	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.3056
p.A630V	DO234270	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.25
p.A630V	DO42673	UCEC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.25
p.P613L	DO234341	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1111
p.E877A	DO11567	GBM	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.25
p.E877A	DO11567	GBM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.25
p.D625N	DO14160	HNSC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.6932
p.P663A	DO229505	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.0833
p.P663A	DO230659	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.0833
p.P663A	DO231140	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.0833
p.P663A	DO228941	LICA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.0833
p.P663A	DO231102	LUSC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.0833
p.R687I	DO229027	LICA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1111
p.Q672E	DO48694	LIRI	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation altering degron motif	0.6744
p.L614M	DO23566	LUAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1389
p.L670P	DO224610	LUSC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.2778
p.N621I	DO231057	LUSC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.728
p.G880W	DO26466	LUSC	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.1667
p.G880W	DO26466	LUSC	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.1667
p.E873K	DO45482	LUSC	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation altering degron motif	0.7022
p.E873K	DO45482	LUSC	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation altering degron motif	0.7022
p.I667V	DO36347	PRAD	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.1944
p.G866E	DO37823	SKCM	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.25
p.G866E	DO37823	SKCM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.2778
p.K867N	DO37452	SKCM	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation rewiring degron network	0.2778
p.K867N	DO37452	SKCM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.3056
p.E622K	DO51301	SKCM	ICGC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.7022
p.G673E	DO51277	SKCM	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation altering degron motif	0.7199
p.P869H	DO38217	STAD	ICGC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation altering degron motif	0.7694
p.P869H	DO38217	STAD	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation altering degron motif	0.7694
p.E633D	SIDM00993	Plasma Cell Myeloma	GDSC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1667
p.E633D	AMO-1	haematopoietic and lymphoid tissue	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation rewiring degron network	0.1667
p.I871V	SIDM00773	Non-Cancerous	GDSC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation altering degron motif	0.5965
p.I871V	SIDM00773	Non-Cancerous	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation altering degron motif	0.5965
p.I871V	SIDM00774	Breast Carcinoma	GDSC	IHIFNE	LIG_APCC_ABBA_1	869:874	Mutation altering degron motif	0.5965
p.I871V	SIDM00774	Breast Carcinoma	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation altering degron motif	0.5965
p.G858E	SIDM01174	Cervical Carcinoma	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.0556
p.G858E	SW756	cervix	COSMIC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	868:874	Mutation rewiring degron network	0.0556
p.S627L	SIDM00280	Gastric Carcinoma	GDSC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.7667
p.S627L	ECC10	stomach	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.7667
p.S668Y	SIDM00534	Colorectal Carcinoma	GDSC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.2222
p.S668Y	HT-115	large intestine	COSMIC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.2222
p.A682S	SIDM01664	Prostate Carcinoma	GDSC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.25
p.E622D	ACH-000838	Myeloma	CCLE	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.6758
p.E622D	AMO-1	haematopoietic and lymphoid tissue	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	621:627	Mutation altering degron motif	0.6758
p.A671S	ACH-000952	Prostate Cancer	CCLE	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.3056
p.S668P	TT	thyroid	COSMIC	PSPTPVIS	DEG_SCF_FBW7_1	672:679	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITIH2

UniProt ID: P19823

Entrez ID: 3698

Protein name: Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITIH2 in