DegronMD

Uniprot ID: P19823

Source protein: Inter-alpha-trypsin inhibitor heavy chain H2

Source gene: ITIH2

Class: DEG_SCF_FBW7_1

Location: 621:627

E3 ligase: FBXW7

DEGRON score: 0.6106

ASA_SCORE: 28.1571

COIL: 0.587

CONS_SCORE: 0.6254

DSS_SCORE: 0.2626

HELIX: 0.2957

FCONS_SCORE: 1.3621

RIG_SCORE: 0.8013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S616Y	TCGA-05-5425	LUAD	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.1944
p.L625M	TCGA-55-8616	LUAD	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.5999
p.Q614R	TCGA-A5-A0VQ	UCEC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.1389
p.S611L	TCGA-B5-A3FA	UCEC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.0556
p.D636N	TCGA-CV-7568	HNSC	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.0833
p.E633K	TCGA-Z2-A8RT	SKCM	TCGA	IVTPLTS	DEG_SCF_FBW7_1	0.1667
p.S616L	DO218173	BRCA	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.1944
p.S616L	ACH-000560	Gastric Cancer	CCLE	IVTPLTS	DEG_SCF_FBW7_1	0.1944
p.S616L	ECC10	stomach	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	0.1944
p.M628V	DO8826	COAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.3056
p.Q635H	DO227984	COCA	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.1111
p.E620G	DO50406	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.3056
p.A630V	DO234270	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.25
p.A630V	DO42673	UCEC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.25
p.P613L	DO234341	ESAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.1111
p.D625N	DO14160	HNSC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.6932
p.L614M	DO23566	LUAD	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.1389
p.N621I	DO231057	LUSC	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.728
p.E622K	DO51301	SKCM	ICGC	IVTPLTS	DEG_SCF_FBW7_1	0.7022
p.E633D	SIDM00993	Plasma Cell Myeloma	GDSC	IVTPLTS	DEG_SCF_FBW7_1	0.1667
p.E633D	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	0.1667
p.S627L	SIDM00280	Gastric Carcinoma	GDSC	IVTPLTS	DEG_SCF_FBW7_1	0.7667
p.S627L	ECC10	stomach	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	0.7667
p.E622D	ACH-000838	Myeloma	CCLE	IVTPLTS	DEG_SCF_FBW7_1	0.6758
p.E622D	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	IVTPLTS	DEG_SCF_FBW7_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19823	Inter-alpha-trypsin inhibitor heavy chain H2	DEG_SCF_FBW7_1	621:627	IVTPLTS	FBXW7	0.6106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons