DegronMD

Uniprot ID: P19823

Source protein: Inter-alpha-trypsin inhibitor heavy chain H2

Source gene: ITIH2

Class: DEG_SCF_FBW7_1

Location: 672:679

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 67.6125

COIL: 0.7404

CONS_SCORE: 0.3504

DSS_SCORE: 0.4666

HELIX: 0.0746

FCONS_SCORE: 1.1519

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W669R	TCGA-50-5930	LUAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	0.25
p.I678V	TCGA-CH-5767	PRAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	0.5965
p.P667L	TCGA-FC-A8O0	PRAD	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	0.1944
p.Q686E	TCGA-VS-A8EL	CESC	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	0.1389
p.G684E	TCGA-W3-AA1W	SKCM	TCGA	PSPTPVIS	DEG_SCF_FBW7_1	0.1944
p.V666M	DO48424	BLCA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.1667
p.T680M	DO222486	BTCA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.3056
p.Q675E	DO51624	CESC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.6744
p.P663A	DO229505	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.0833
p.P663A	DO230659	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.0833
p.P663A	DO231140	LAML	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.0833
p.P663A	DO228941	LICA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.0833
p.P663A	DO231102	LUSC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.0833
p.R687I	DO229027	LICA	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.1111
p.Q672E	DO48694	LIRI	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.6744
p.L670P	DO224610	LUSC	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.2778
p.I667V	DO36347	PRAD	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.1944
p.G673E	DO51277	SKCM	ICGC	PSPTPVIS	DEG_SCF_FBW7_1	0.7199
p.S668Y	SIDM00534	Colorectal Carcinoma	GDSC	PSPTPVIS	DEG_SCF_FBW7_1	0.2222
p.S668Y	HT-115	large_intestine	COSMIC	PSPTPVIS	DEG_SCF_FBW7_1	0.2222
p.A682S	SIDM01664	Prostate Carcinoma	GDSC	PSPTPVIS	DEG_SCF_FBW7_1	0.25
p.A671S	ACH-000952	Prostate Cancer	CCLE	PSPTPVIS	DEG_SCF_FBW7_1	0.3056
p.S668P	TT	thyroid	COSMIC	PSPTPVIS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19823	Inter-alpha-trypsin inhibitor heavy chain H2	DEG_SCF_FBW7_1	672:679	PSPTPVIS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons