DegronMD

Uniprot ID: P19823

Source protein: Inter-alpha-trypsin inhibitor heavy chain H2

Source gene: ITIH2

Class: LIG_APCC_ABBAyCdc20_2

Location: 868:874

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5599

ASA_SCORE: 67.1714

COIL: 0.3706

CONS_SCORE: 0.2919

DSS_SCORE: 0.6201

HELIX: 0.0533

FCONS_SCORE: 0.8325

RIG_SCORE: 0.7564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E884K	TCGA-90-A4ED	LUSC	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P880H	TCGA-BR-6566	STAD	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G858R	TCGA-EE-A29M	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G877E	TCGA-EE-A2GO	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.25
p.K878N	TCGA-ER-A19N	SKCM	TCGA	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.3333
p.E877A	DO11567	GBM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.25
p.G880W	DO26466	LUSC	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E873K	DO45482	LUSC	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.G866E	DO37823	SKCM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K867N	DO37452	SKCM	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P869H	DO38217	STAD	ICGC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.7694
p.I871V	SIDM00773	Non-Cancerous	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I871V	SIDM00774	Breast Carcinoma	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.5965
p.G858E	SIDM01174	Cervical Carcinoma	GDSC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G858E	SW756	cervix	COSMIC	KIHIFNE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19823	Inter-alpha-trypsin inhibitor heavy chain H2	LIG_APCC_ABBAyCdc20_2	868:874	KIHIFNE	APC,CDC20,FZR1	0.5599	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons