DegronMD

Uniprot ID: Q9Y6Y1

Source protein: Calmodulin-binding transcription activator 1

Source gene: CAMTA1

Class: DEG_SCF_FBW7_1

Location: 608:615

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 78.6

COIL: 0.847

CONS_SCORE: 0.3571

DSS_SCORE: 0.6439

HELIX: 0.0815

FCONS_SCORE: 1.1158

RIG_SCORE: 0.6324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D620N	TCGA-22-5481	LUSC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.1944
p.D620N	DO27160	LUSC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.1944
p.T602M	TCGA-A6-5661	COAD	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.1667
p.T602M	DO8634	COAD	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.1667
p.T602M	DO222826	COCA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.1667
p.P612S	TCGA-AA-3856	COAD	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.6752
p.P612S	DO10292	COAD	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.6752
p.F617L	TCGA-AX-A2HC	UCEC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.2778
p.F617L	DO41572	UCEC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.2778
p.F617S	TCGA-BA-A8YP	HNSC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.2778
p.F617S	DO52036	HNSC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.2778
p.F616L	TCGA-EO-A3B0	UCEC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	0.3056
p.F616L	DO219773	UCEC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.3056
p.F616L	SIDM00534	Colorectal Carcinoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	0.3056
p.F616L	ACH-000986	Colon/Colorectal Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	0.3056
p.F616L	HT-115	large_intestine	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	0.3056
p.T611N	DO223041	ESCA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.7055
p.P614L	DO233109	GACA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.6471
p.Q601H	DO229028	LICA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	0.1389
p.G603A	SIDM00545	Melanoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	0.1944
p.G603A	ACH-000987	Skin Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	0.1944
p.G603A	Mewo	skin	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	0.1944
p.L618M	SIDM00489	Oral Cavity Carcinoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	0.25
p.L618M	ACH-002043	Head and Neck Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	0.25
p.L618M	Ca9-22	upper_aerodigestive_tract	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	0.25
p.A621T	ACH-000937	Leukemia	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Y1	Calmodulin-binding transcription activator 1	DEG_SCF_FBW7_1	608:615	IHQTPSPS	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IHQTPSPS

Degron related mutations and impact score

Drug responses associated with CAMTA1 mutations

All proteins holding degron of IHQTPSPS