DegronMD - Q9Y6Y1(CAMTA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T415S	TCGA-06-1805	GBM	TCGA	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.3056
p.T415S	DO11567	GBM	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.3056
p.D620N	TCGA-22-5481	LUSC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1944
p.D620N	DO27160	LUSC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1944
p.A416D	TCGA-A5-A1OF	UCEC	TCGA	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.2778
p.A416D	DO42568	UCEC	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.2778
p.T602M	TCGA-A6-5661	COAD	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1667
p.T602M	DO8634	COAD	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1667
p.T602M	DO222826	COCA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1667
p.P612S	TCGA-AA-3856	COAD	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation altering degron motif	0.6752
p.P612S	DO10292	COAD	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation altering degron motif	0.6752
p.F617L	TCGA-AX-A2HC	UCEC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.2778
p.F617L	DO41572	UCEC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.2778
p.F617S	TCGA-BA-A8YP	HNSC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.2778
p.F617S	DO52036	HNSC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.2778
p.F616L	TCGA-EO-A3B0	UCEC	TCGA	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.3056
p.F616L	DO219773	UCEC	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.3056
p.F616L	SIDM00534	Colorectal Carcinoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.3056
p.F616L	ACH-000986	Colon/Colorectal Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.3056
p.F616L	HT-115	large intestine	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.3056
p.A416T	TCGA-LL-A7T0	BRCA	TCGA	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.2778
p.A416T	DO50066	BRCA	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.2778
p.T611N	DO223041	ESCA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation altering degron motif	0.7055
p.P614L	DO233109	GACA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation altering degron motif	0.6471
p.Q601H	DO229028	LICA	ICGC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1389
p.A397G	DO228338	MALY	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0833
p.A397G	SIDM00948	Burkitt's Lymphoma	GDSC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0833
p.A397G	ACH-002232	Lymphoma	CCLE	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0833
p.A397G	DG-75	haematopoietic and lymphoid tissue	COSMIC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0833
p.S413F	DO220899	MELA	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation altering degron motif	0.6871
p.Y410H	DO232224	PBCA	ICGC	NEAVYTMSP	CBL_PTK	406:414	Mutation altering degron motif	0.7229
p.G603A	SIDM00545	Melanoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1944
p.G603A	ACH-000987	Skin Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1944
p.G603A	Mewo	skin	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1944
p.T398M	SIDM00660	Colorectal Carcinoma	GDSC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.1111
p.T398M	ACH-000985	Colon/Colorectal Cancer	CCLE	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.1111
p.T398M	LS-411N	large intestine	COSMIC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.1111
p.L618M	SIDM00489	Oral Cavity Carcinoma	GDSC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.25
p.L618M	ACH-002043	Head and Neck Cancer	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.25
p.L618M	Ca9-22	upper aerodigestive tract	COSMIC	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.25
p.S396R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0556
p.S396R	ACH-000945	Lung Cancer	CCLE	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0556
p.S396R	NCI-H650	lung	COSMIC	NEAVYTMSP	CBL_PTK	406:414	Mutation rewiring degron network	0.0556
p.A621T	ACH-000937	Leukemia	CCLE	IHQTPSPS	DEG_SCF_FBW7_1	608:615	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAMTA1

UniProt ID: Q9Y6Y1

Entrez ID: 23261

Protein name: Calmodulin-binding transcription activator 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAMTA1 in