DegronMD

Uniprot ID: Q9Y6Y1

Source protein: Calmodulin-binding transcription activator 1

Source gene: CAMTA1

Class: CBL_PTK

Location: 406:414

E3 ligase: CBL

DEGRON score: 0.992

ASA_SCORE: 73.8667

COIL: 0.7177

CONS_SCORE: 0.3677

DSS_SCORE: 0.3652

HELIX: 0.1158

FCONS_SCORE: 1.0436

RIG_SCORE: 0.7718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T415S	TCGA-06-1805	GBM	TCGA	NEAVYTMSP	CBL_PTK	0.3056
p.T415S	DO11567	GBM	ICGC	NEAVYTMSP	CBL_PTK	0.3056
p.A416D	TCGA-A5-A1OF	UCEC	TCGA	NEAVYTMSP	CBL_PTK	0.2778
p.A416D	DO42568	UCEC	ICGC	NEAVYTMSP	CBL_PTK	0.2778
p.A416T	TCGA-LL-A7T0	BRCA	TCGA	NEAVYTMSP	CBL_PTK	0.2778
p.A416T	DO50066	BRCA	ICGC	NEAVYTMSP	CBL_PTK	0.2778
p.A397G	DO228338	MALY	ICGC	NEAVYTMSP	CBL_PTK	0.0833
p.A397G	SIDM00948	Burkitt's Lymphoma	GDSC	NEAVYTMSP	CBL_PTK	0.0833
p.A397G	ACH-002232	Lymphoma	CCLE	NEAVYTMSP	CBL_PTK	0.0833
p.A397G	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	NEAVYTMSP	CBL_PTK	0.0833
p.S413F	DO220899	MELA	ICGC	NEAVYTMSP	CBL_PTK	0.6871
p.Y410H	DO232224	PBCA	ICGC	NEAVYTMSP	CBL_PTK	0.7229
p.T398M	SIDM00660	Colorectal Carcinoma	GDSC	NEAVYTMSP	CBL_PTK	0.1111
p.T398M	ACH-000985	Colon/Colorectal Cancer	CCLE	NEAVYTMSP	CBL_PTK	0.1111
p.T398M	LS-411N	large_intestine	COSMIC	NEAVYTMSP	CBL_PTK	0.1111
p.S396R	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	NEAVYTMSP	CBL_PTK	0.0556
p.S396R	ACH-000945	Lung Cancer	CCLE	NEAVYTMSP	CBL_PTK	0.0556
p.S396R	NCI-H650	lung	COSMIC	NEAVYTMSP	CBL_PTK	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6Y1	Calmodulin-binding transcription activator 1	CBL_PTK	406:414	NEAVYTMSP	CBL	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons