DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 2038:2045

E3 ligase: FBXW7

DEGRON score: 0.8195

ASA_SCORE: 91.6125

COIL: 0.9346

CONS_SCORE: 0.2763

DSS_SCORE: 0.6532

HELIX: 0.0109

FCONS_SCORE: 0.9758

RIG_SCORE: 0.628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2046D	TCGA-56-A4BW	LUSC	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.V2046D	DO45441	LUSC	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.A2036V	TCGA-BG-A0MT	UCEC	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.2778
p.A2036V	DO41698	UCEC	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2778
p.S2035F	TCGA-CQ-5333	HNSC	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.25
p.S2035F	TCGA-D6-A6EQ	HNSC	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.25
p.S2035F	DO14218	HNSC	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.25
p.S2035F	DO52085	HNSC	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.25
p.G2044D	TCGA-ER-A193	SKCM	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.6087
p.G2044D	DO47368	SKCM	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.6087
p.I2038M	TCGA-ZF-A9RN	BLCA	TCGA	IHSTPTGT	DEG_SCF_FBW7_1	0.6507
p.I2038M	DO219081	BLCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.6507
p.L2052V	DO224668	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1389
p.L2052V	DO224726	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1389
p.P2049L	DO224661	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO224616	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO222709	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO222849	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229010	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229013	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229016	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229003	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229005	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.P2049L	DO229211	THCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.2222
p.T2030A	DO224671	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO222884	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229013	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229016	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229003	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229005	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229213	THCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030A	DO229250	THCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.A2033S	DO224671	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2033S	DO222884	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2033S	DO229013	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2033S	DO229016	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2033S	DO229003	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2033S	DO229173	THCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.1944
p.A2054V	DO224731	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.A2054V	DO229010	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.A2054V	DO229013	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.A2054V	DO229016	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.A2054V	DO229003	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.A2054V	DO229005	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.H2029R	DO224744	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0833
p.T2028P	DO224744	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.0556
p.V2046I	DO229010	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.V2046I	DO229013	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.V2046I	DO229016	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.V2046I	DO229003	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.V2046I	DO229005	COCA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.3056
p.T2041M	DO233864	GACA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T2041M	DO35442	PACA	ICGC	IHSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T2041M	HEC-1	endometrium	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T2030I	SIDM00967	Ovarian Carcinoma	GDSC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2030I	OVCA420	ovary	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.1111
p.T2051M	SIDM00254	Neuroblastoma	GDSC	IHSTPTGT	DEG_SCF_FBW7_1	0.1667
p.T2051M	NB5	autonomic_ganglia	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.1667
p.T2051M	NCI-H250	lung	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.1667
p.T2051M	NCI-H810	lung	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.1667
p.T2051M	NCI-H748	lung	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.1667
p.H2039P	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.6583
p.H2039P	SW982	soft_tissue	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.6583
p.H2039P	OV-56	ovary	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.6583
p.H2039P	GAMG	central_nervous_system	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.6583
p.H2039P	SW1990	pancreas	COSMIC	IHSTPTGT	DEG_SCF_FBW7_1	0.6583

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IHSTPTGT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of IHSTPTGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	2038:2045	IHSTPTGT	FBXW7	0.8195	More...