DegronMD

Uniprot ID: O96020

Source protein: G1/S-specific cyclin-E2

Source gene: CCNE2

Class: DEG_SCF_FBW7_2

Location: 71:78

E3 ligase: FBXW7

DEGRON score: 0.8638

ASA_SCORE: 107.5

COIL: 0.8671

CONS_SCORE: 0.4235

DSS_SCORE: 0.2677

HELIX: 0.0299

FCONS_SCORE: 1.0578

RIG_SCORE: 0.8214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S67G	TCGA-B5-A1MX	UCEC	TCGA	IIETPHKE	DEG_SCF_FBW7_2	0.6667
p.S67G	DO41999	UCEC	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.6667
p.F84L	TCGA-D1-A16Y	UCEC	TCGA	IIETPHKE	DEG_SCF_FBW7_2	0.1667
p.F84L	DO41524	UCEC	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.1667
p.E78K	TCGA-YG-AA3O	SKCM	TCGA	IIETPHKE	DEG_SCF_FBW7_2	0.7022
p.E78K	DO51299	SKCM	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.7022
p.D83N	TCGA-ZF-A9R0	BLCA	TCGA	IIETPHKE	DEG_SCF_FBW7_2	0.1944
p.D83N	DO219055	BLCA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.1944
p.T74K	DO229026	LICA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.8417
p.R86G	DO229272	THCA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96020	G1/S-specific cyclin-E2	DEG_SCF_FBW7_2	71:78	IIETPHKE	FBXW7	0.8638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons