DegronMD - O96020(CCNE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H404Y	TCGA-62-A46R	LUAD	TCGA	IMTPPKS	DEG_SCF_FBW7_1	390:396	Mutation rewiring degron network	0.1111
p.H404Y	DO45355	LUAD	ICGC	IMTPPKS	DEG_SCF_FBW7_1	390:396	Mutation rewiring degron network	0.1111
p.S67G	TCGA-B5-A1MX	UCEC	TCGA	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation blocking phosphorylation signal	0.6667
p.S67G	DO41999	UCEC	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation blocking phosphorylation signal	0.6667
p.F84L	TCGA-D1-A16Y	UCEC	TCGA	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation rewiring degron network	0.1667
p.F84L	DO41524	UCEC	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation rewiring degron network	0.1667
p.E78K	TCGA-YG-AA3O	SKCM	TCGA	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation altering degron motif	0.7022
p.E78K	DO51299	SKCM	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation altering degron motif	0.7022
p.D83N	TCGA-ZF-A9R0	BLCA	TCGA	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation rewiring degron network	0.1944
p.D83N	DO219055	BLCA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation rewiring degron network	0.1944
p.T392K	DO229026	LICA	ICGC	IMTPPKS	DEG_SCF_FBW7_1	390:396	Mutation altering degron motif	0.8417
p.T74K	DO229026	LICA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation altering degron motif	0.8417
p.Q381K	DO229031	LICA	ICGC	IMTPPKS	DEG_SCF_FBW7_1	390:396	Mutation rewiring degron network	0.0833
p.R86G	DO229272	THCA	ICGC	IIETPHKE	DEG_SCF_FBW7_2	71:78	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons