DegronMD

Uniprot ID: O96020

Source protein: G1/S-specific cyclin-E2

Source gene: CCNE2

Class: DEG_SCF_FBW7_1

Location: 390:396

E3 ligase: FBXW7

DEGRON score: 0.9783

ASA_SCORE: 70.5429

COIL: 0.8797

CONS_SCORE: 0.3406

DSS_SCORE: 0.6503

HELIX: 0.0089

FCONS_SCORE: 0.9568

RIG_SCORE: 0.642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H404Y	TCGA-62-A46R	LUAD	TCGA	IMTPPKS	DEG_SCF_FBW7_1	0.1111
p.H404Y	DO45355	LUAD	ICGC	IMTPPKS	DEG_SCF_FBW7_1	0.1111
p.T392K	DO229026	LICA	ICGC	IMTPPKS	DEG_SCF_FBW7_1	0.8417
p.Q381K	DO229031	LICA	ICGC	IMTPPKS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96020	G1/S-specific cyclin-E2	DEG_SCF_FBW7_1	390:396	IMTPPKS	FBXW7	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons