DegronMD

Uniprot ID: Q9BYV8

Source protein: Centrosomal protein of 41 kDa

Source gene: CEP41

Class: LIG_APCC_ABBA_1

Location: 222:227

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 11.55

COIL: 0.2552

CONS_SCORE: 0.7166

DSS_SCORE: 0.1275

HELIX: 0.0078

FCONS_SCORE: 1.2834

RIG_SCORE: 0.9153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D226N	TCGA-BH-A1FC	BRCA	TCGA	IILYDD	LIG_APCC_ABBA_1	0.5821
p.D226N	DO5661	BRCA	ICGC	IILYDD	LIG_APCC_ABBA_1	0.5821
p.L224V	TCGA-IR-A3LK	CESC	TCGA	IILYDD	LIG_APCC_ABBA_1	0.5654
p.L224V	DO44299	CESC	ICGC	IILYDD	LIG_APCC_ABBA_1	0.5654
p.A217V	DO222737	COCA	ICGC	IILYDD	LIG_APCC_ABBA_1	0.1944
p.A235E	DO229028	LICA	ICGC	IILYDD	LIG_APCC_ABBA_1	0.1111
p.M223I	HEC-1	endometrium	COSMIC	IILYDD	LIG_APCC_ABBA_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYV8	Centrosomal protein of 41 kDa	LIG_APCC_ABBA_1	222:227	IILYDD	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons