DegronMD - Q9BYV8(CEP41)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N127S	TCGA-AP-A051	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.N127S	TCGA-B8-5159	KIRC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.N127S	DO17597	KIRC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.N127S	DO42673	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1111
p.G130R	TCGA-AP-A059	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.G130R	DO41361	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.A129T	TCGA-B5-A11E	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1667
p.A129T	DO41644	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1667
p.D226N	TCGA-BH-A1FC	BRCA	TCGA	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation altering degron motif	0.5821
p.D226N	DO5661	BRCA	ICGC	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation altering degron motif	0.5821
p.A131T	TCGA-D5-6928	COAD	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.2222
p.A131T	DO7776	COAD	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.2222
p.E148K	TCGA-F5-6814	READ	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.E148K	DO36556	READ	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.L224V	TCGA-IR-A3LK	CESC	TCGA	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation altering degron motif	0.5654
p.L224V	DO44299	CESC	ICGC	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation altering degron motif	0.5654
p.A217V	DO222737	COCA	ICGC	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation rewiring degron network	0.1944
p.R136H	DO234209	ESAD	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.8244
p.A235E	DO229028	LICA	ICGC	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation rewiring degron network	0.1111
p.V142F	DO231186	LUSC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.7068
p.D133H	DO227570	PACA	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.2778
p.G130E	SIDM00685	Glioblastoma	GDSC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.G130E	ACH-000819	Brain Cancer	CCLE	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.G130E	LN-18	central nervous system	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.1944
p.P145R	MDST8	large intestine	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation rewiring degron network	0.2778
p.M223I	HEC-1	endometrium	COSMIC	IILYDD	LIG_APCC_ABBA_1	222:227	Mutation altering degron motif	0.7618
p.A143S	NCI-H250	lung	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	135:143	Mutation altering degron motif	0.7588

Kaplan plot for CEP41 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP41

UniProt ID: Q9BYV8

Entrez ID: 95681

Protein name: Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP41 in