DegronMD

Uniprot ID: Q9BYV8

Source protein: Centrosomal protein of 41 kDa

Source gene: CEP41

Class: DEG_APCC_DBOX_1

Location: 135:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5212

ASA_SCORE: 70.5

COIL: 0.543

CONS_SCORE: 0.5164

DSS_SCORE: 0.5467

HELIX: 0.2682

FCONS_SCORE: 1.3097

RIG_SCORE: 0.6865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N127S	TCGA-AP-A051	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.1111
p.N127S	TCGA-B8-5159	KIRC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.1111
p.N127S	DO17597	KIRC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1111
p.N127S	DO42673	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1111
p.G130R	TCGA-AP-A059	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.G130R	DO41361	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.A129T	TCGA-B5-A11E	UCEC	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.1667
p.A129T	DO41644	UCEC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1667
p.A131T	TCGA-D5-6928	COAD	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.2222
p.A131T	DO7776	COAD	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.2222
p.E148K	TCGA-F5-6814	READ	TCGA	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.E148K	DO36556	READ	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.R136H	DO234209	ESAD	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.8244
p.V142F	DO231186	LUSC	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.7068
p.D133H	DO227570	PACA	ICGC	SRSTLQSVI	DEG_APCC_DBOX_1	0.2778
p.G130E	SIDM00685	Glioblastoma	GDSC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.G130E	ACH-000819	Brain Cancer	CCLE	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.G130E	LN-18	central_nervous_system	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	0.1944
p.P145R	MDST8	large_intestine	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	0.2778
p.A143S	NCI-H250	lung	COSMIC	SRSTLQSVI	DEG_APCC_DBOX_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYV8	Centrosomal protein of 41 kDa	DEG_APCC_DBOX_1	135:143	SRSTLQSVI	APC,CDC20,FZR1	0.5212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons