DegronMD

Uniprot ID: Q14703

Source protein: Membrane-bound transcription factor site-1 protease

Source gene: MBTPS1

Class: DEG_SCF_FBW7_1

Location: 613:620

E3 ligase: FBXW7

DEGRON score: 0.6475

ASA_SCORE: 61.575

COIL: 0.7753

CONS_SCORE: 0.3826

DSS_SCORE: 0.3342

HELIX: 0.059

FCONS_SCORE: 1.0081

RIG_SCORE: 0.7514

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R619Q	TCGA-AG-A002	READ	TCGA	IIPTPPRS	DEG_SCF_FBW7_1	0.6218
p.K621R	TCGA-NK-A5CR	LUSC	TCGA	IIPTPPRS	DEG_SCF_FBW7_1	0.3056
p.K621R	DO219207	LUSC	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.3056
p.P618L	TCGA-XF-AAMH	BLCA	TCGA	IIPTPPRS	DEG_SCF_FBW7_1	0.6471
p.P618L	DO51931	BLCA	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.6471
p.P618Q	DO228971	LICA	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.5924
p.P618S	DO220906	MELA	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.5641
p.P615S	DO229494	SKCA	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.5641
p.D626Y	DO229259	THCA	ICGC	IIPTPPRS	DEG_SCF_FBW7_1	0.1667

Drug responses associated with MBTPS1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00533	PAAD\|pancreas	p.S182N (No)	GDSC	FTY-720	25.0473
SIDM00729	LUAD\|lung_NSCLC_adenocarcinoma	p.P928A (No)	GDSC	FTY-720	18.9981
SIDM00190	SKCM\|melanoma	p.P1003S (No)	GDSC	FTY-720	8.4615
SIDM00778	COREAD\|large_intestine	p.G526A (No)	GDSC	FTY-720	6.9014
SIDM00588	HNSC\|head_and_neck	p.R191H (No)	GDSC	FTY-720	6.3898
SIDM00087	MM\|myeloma	p.R712K (No)	GDSC	FTY-720	7.4446
SIDM01036	MM\|haematopoietic_neoplasm_other	p.S411L (No)	GDSC	FTY-720	5.9568
SIDM00966	OV\|ovary	p.F807L (No)	GDSC	FTY-720	6.7255
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R855* (No)	GDSC	FTY-720	4.8588
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T242M (No)	GDSC	FTY-720	4.8588
SIDM00997	THCA\|thyroid	p.S259G (No)	GDSC	FTY-720	8.1576
SIDM00603	HNSC\|head_and_neck	p.L9F (No)	GDSC	FTY-720	6.2779
SIDM01056	BRCA\|breast	p.A788S (No)	GDSC	FTY-720	3.497
SIDM00214	COREAD\|large_intestine	p.R969H (No)	GDSC	FTY-720	20.2288
SIDM01088	UNCLASSIFIED\|endometrium	p.M645T (No)	GDSC	FTY-720	2.7114
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R696T (No)	GDSC	FTY-720	17.7684
SIDM01043	UNCLASSIFIED\|endometrium	p.R1037H (No)	GDSC	FTY-720	12.0739
SIDM00194	COREAD\|large_intestine	p.S166T (No)	GDSC	FTY-720	21.8057
SIDM01045	UCEC\|endometrium	p.V322M (No)	GDSC	FTY-720	8.9738
SIDM00137	LUAD\|lung_NSCLC_adenocarcinoma	p.R993H (No)	GDSC	FTY-720	14.5437
SIDM00333	UCEC\|endometrium	p.P690S (No)	GDSC	FTY-720	11.0891
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.R130Q (No)	GDSC	FTY-720	1.939
SIDM00507	UNCLASSIFIED\|lung_other	p.H906Y (No)	GDSC	FTY-720	17.009
SIDM00507	UNCLASSIFIED\|lung_other	p.L306V (No)	GDSC	FTY-720	17.009
SIDM00216	COREAD\|large_intestine	p.A112V (No)	GDSC	FTY-720	15.903
SIDM00479	ESCA\|oesophagus	p.A588P (No)	GDSC	FTY-720	7.1799
SIDM00150	COREAD\|large_intestine	p.V696M (No)	GDSC	FTY-720	7.1859
SIDM01176	ALL\|lymphoblastic_leukemia	p.K920N (No)	GDSC	FTY-720	5.1762
SIDM00197	UNCLASSIFIED\|ewings_sarcoma	p.R130Q (No)	GDSC	FTY-720	9.6823
SIDM00783	COREAD\|large_intestine	p.P1028S (No)	GDSC	FTY-720	6.4394
SIDM00520	MESO\|mesothelioma	p.I833V (No)	GDSC	FTY-720	17.9349
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.H713R (No)	GDSC	FTY-720	2.9216
SIDM00954	BRCA\|breast	p.A729V (No)	GDSC	FTY-720	2.3719
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.N597fs*9 (No)	GDSC	FTY-720	4.0549
SIDM00257	NB\|neuroblastoma	p.A729V (No)	GDSC	FTY-720	5.8337
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P557S (No)	GDSC	FTY-720	11.1566
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R1031G (No)	GDSC	FTY-720	25.8454
SIDM00487	COREAD\|large_intestine	p.P748L (No)	GDSC	FTY-720	15.36
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.K920N (No)	GDSC	FTY-720	8.0006
SIDM01169	OV\|ovary	p.R632C (No)	GDSC	FTY-720	12.8585
SIDM00963	BRCA\|breast	p.G220E (No)	GDSC	FTY-720	3.6806
SIDM00290	STAD\|stomach	p.S181* (No)	GDSC	FTY-720	3.0109
SIDM00642	SCLC\|lung_small_cell_carcinoma	p.I331T (No)	GDSC	FTY-720	23.1793
SIDM01023	LAML\|acute_myeloid_leukaemia	p.V814I (No)	GDSC	FTY-720	30.495
SIDM00803	KIRC\|kidney	p.T242M (No)	GDSC	FTY-720	6.6533
SIDM00604	HNSC\|head_and_neck	p.A448T (No)	GDSC	FTY-720	7.2465
SIDM00444	ESCA\|oesophagus	p.I833V (No)	GDSC	FTY-720	6.7663
SIDM00884	BRCA\|breast	p.L698* (No)	GDSC	FTY-720	2.2761
SIDM00537	COREAD\|large_intestine	p.L185P (No)	GDSC	FTY-720	17.1794
SIDM00537	COREAD\|large_intestine	p.V12E (No)	GDSC	FTY-720	17.1794
SIDM00105	OV\|ovary	p.A712V (No)	GDSC	FTY-720	13.2435
SIDM00837	COREAD\|large_intestine	p.C16R (No)	GDSC	FTY-720	19.4483
SIDM00118	COREAD\|large_intestine	p.K299Q (No)	GDSC	FTY-720	6.0614
SIDM01149	SCLC\|lung_small_cell_carcinoma	p.T593K (No)	GDSC	FTY-720	6.266

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IIPTPPRS

Degron related mutations and impact score

Drug responses associated with MBTPS1 mutations

All proteins holding degron of IIPTPPRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14703	Membrane-bound transcription factor site-1 protease	DEG_SCF_FBW7_1	613:620	IIPTPPRS	FBXW7	0.6475	More...