DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_APCC_TPR_1

Location: 509:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.901

ASA_SCORE: 130.1667

COIL: 0.9477

CONS_SCORE: 0.4282

DSS_SCORE: 0.8896

HELIX: 0.0353

FCONS_SCORE: 0.7256

RIG_SCORE: 0.8077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T502M	TCGA-26-5136	GBM	TCGA	IIR	DEG_APCC_TPR_1	0.1389
p.T502M	DO11471	GBM	ICGC	IIR	DEG_APCC_TPR_1	0.1389
p.I510T	TCGA-GD-A3OS	BLCA	TCGA	IIR	DEG_APCC_TPR_1	0.7078
p.I510T	DO598	BLCA	ICGC	IIR	DEG_APCC_TPR_1	0.7078
p.S506W	TCGA-UF-A7JV	HNSC	TCGA	IIR	DEG_APCC_TPR_1	0.25
p.S506W	DO50010	HNSC	ICGC	IIR	DEG_APCC_TPR_1	0.25
p.P508T	DO229031	LICA	ICGC	IIR	DEG_APCC_TPR_1	0.3056
p.D504V	DO45145	LIRI	ICGC	IIR	DEG_APCC_TPR_1	0.1944
p.V501E	DO233293	NACA	ICGC	IIR	DEG_APCC_TPR_1	0.1111
p.P499L	SIDM02035	Colorectal Carcinoma	GDSC	IIR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_APCC_TPR_1	509:511	IIR	APC,CDC20,FZR1	0.901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons