DegronMD

Uniprot ID: Q8N0U7

Source protein: Uncharacterized protein C1orf87

Source gene: C1orf87

Class: DEG_APCC_KENBOX_2

Location: 36:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8022

ASA_SCORE: 98.04

COIL: 0.8166

CONS_SCORE: 0.389

DSS_SCORE: 0.4857

HELIX: 0.1266

FCONS_SCORE: 0.8426

RIG_SCORE: 0.7222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E38D	TCGA-06-5416	GBM	TCGA	IKEND	DEG_APCC_KENBOX_2	0.6758
p.E38D	TCGA-D6-A6ES	HNSC	TCGA	IKEND	DEG_APCC_KENBOX_2	0.6758
p.E38D	DO10880	GBM	ICGC	IKEND	DEG_APCC_KENBOX_2	0.6758
p.E38D	DO52086	HNSC	ICGC	IKEND	DEG_APCC_KENBOX_2	0.6758
p.E38K	TCGA-GN-A4U4	SKCM	TCGA	IKEND	DEG_APCC_KENBOX_2	0.7022
p.E38K	DO222699	MELA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.7022
p.E38K	DO51256	SKCM	ICGC	IKEND	DEG_APCC_KENBOX_2	0.7022
p.Q28K	DO222421	BTCA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.1111
p.H50N	DO228971	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.0556
p.T48K	DO229029	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.1111
p.D40E	DO229028	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.5647
p.H50Q	DO229027	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.0556
p.L30I	DO229032	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.1667
p.P34T	DO229035	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	0.2778
p.P34S	ACH-000328	Brain Cancer	CCLE	IKEND	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0U7	Uncharacterized protein C1orf87	DEG_APCC_KENBOX_2	36:40	IKEND	APC,CDC20,FZR1	0.8022	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons