DegronMD - Q8N0U7(C1orf87)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E38D	TCGA-06-5416	GBM	TCGA	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.6758
p.E38D	TCGA-D6-A6ES	HNSC	TCGA	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.6758
p.E38D	DO10880	GBM	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.6758
p.E38D	DO52086	HNSC	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.6758
p.M424I	TCGA-ER-A19P	SKCM	TCGA	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation altering degron motif	0.6507
p.E38K	TCGA-GN-A4U4	SKCM	TCGA	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.7022
p.E38K	DO222699	MELA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.7022
p.E38K	DO51256	SKCM	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.7022
p.E430K	TCGA-IR-A3LH	CESC	TCGA	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation altering degron motif	0.7022
p.E430K	DO44381	CESC	ICGC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation altering degron motif	0.7022
p.Q28K	DO222421	BTCA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.1111
p.E415V	DO233030	GACA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.0833
p.E415K	DO233855	GACA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.0833
p.E415K	DO220877	MELA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.0833
p.H50N	DO228971	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.0556
p.T48K	DO229029	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.1111
p.D40E	DO229028	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation altering degron motif	0.5647
p.H50Q	DO229027	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.0556
p.L30I	DO229032	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.1667
p.P34T	DO229035	LICA	ICGC	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.2778
p.T426N	DO229041	LICA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation altering degron motif	0.7055
p.L431M	SIDM00534	Colorectal Carcinoma	GDSC	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.3056
p.L431M	ACH-000986	Colon/Colorectal Cancer	CCLE	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.3056
p.P34S	ACH-000328	Brain Cancer	CCLE	IKEND	DEG_APCC_KENBOX_2	36:40	Mutation rewiring degron network	0.2778
p.T421S	ACH-000951	Lung Cancer	CCLE	MKTPEEE	DEG_SCF_FBW7_2	424:430	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1orf87

UniProt ID: Q8N0U7

Entrez ID: 127795

Protein name: Uncharacterized protein C1orf87

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1orf87 in