DegronMD

Uniprot ID: Q8N0U7

Source protein: Uncharacterized protein C1orf87

Source gene: C1orf87

Class: DEG_SCF_FBW7_2

Location: 424:430

E3 ligase: FBXW7

DEGRON score: 0.9752

ASA_SCORE: 88.5857

COIL: 0.5676

CONS_SCORE: 0.4576

DSS_SCORE: 0.8315

HELIX: 0.3971

FCONS_SCORE: 1.2364

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M424I	TCGA-ER-A19P	SKCM	TCGA	MKTPEEE	DEG_SCF_FBW7_2	0.6507
p.E430K	TCGA-IR-A3LH	CESC	TCGA	MKTPEEE	DEG_SCF_FBW7_2	0.7022
p.E430K	DO44381	CESC	ICGC	MKTPEEE	DEG_SCF_FBW7_2	0.7022
p.E415V	DO233030	GACA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	0.0833
p.E415K	DO233855	GACA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	0.0833
p.E415K	DO220877	MELA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	0.0833
p.T426N	DO229041	LICA	ICGC	MKTPEEE	DEG_SCF_FBW7_2	0.7055
p.L431M	SIDM00534	Colorectal Carcinoma	GDSC	MKTPEEE	DEG_SCF_FBW7_2	0.3056
p.L431M	ACH-000986	Colon/Colorectal Cancer	CCLE	MKTPEEE	DEG_SCF_FBW7_2	0.3056
p.T421S	ACH-000951	Lung Cancer	CCLE	MKTPEEE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0U7	Uncharacterized protein C1orf87	DEG_SCF_FBW7_2	424:430	MKTPEEE	FBXW7	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons