DegronMD

Uniprot ID: P13196

Source protein: 5-aminolevulinate synthase, non-specific, mitochondrial

Source gene: ALAS1

Class: DEG_SCF_FBW7_1

Location: 58:65

E3 ligase: FBXW7

DEGRON score: 0.9127

ASA_SCORE: 72.5375

COIL: 0.7049

CONS_SCORE: 0.217

DSS_SCORE: 0.6462

HELIX: 0.2145

FCONS_SCORE: 1.0202

RIG_SCORE: 0.6543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T61N	TCGA-F1-6177	STAD	TCGA	IKETPPAS	DEG_SCF_FBW7_1	0.7055
p.T61N	DO38727	STAD	ICGC	IKETPPAS	DEG_SCF_FBW7_1	0.7055
p.A71T	DO222492	COCA	ICGC	IKETPPAS	DEG_SCF_FBW7_1	0.1667
p.K69E	DO229016	COCA	ICGC	IKETPPAS	DEG_SCF_FBW7_1	0.3333
p.K69E	SIDM00064	Hepatocellular Carcinoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.3333
p.S65G	SIDM00607	Glioblastoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.6993
p.S65G	SIDM00580	Acute Myeloid Leukemia	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.6993
p.S65G	SIDM01018	Hodgkin's Lymphoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.6993
p.S65G	SIDM01463	Endometrial Carcinoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.6993
p.S65G	SIDM01559	Melanoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13196	5-aminolevulinate synthase, non-specific, mitochondrial	DEG_SCF_FBW7_1	58:65	IKETPPAS	FBXW7	0.9127	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons