DegronMD - P13196(ALAS1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V75I	TCGA-A5-A0G1	UCEC	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5965
p.V75I	DO223077	ESCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5965
p.V75I	DO42472	UCEC	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5965
p.D80N	TCGA-AC-A23H	BRCA	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5821
p.D80N	DO2401	BRCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5821
p.V75A	TCGA-BP-4998	KIRC	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.6936
p.V75A	DO20210	KIRC	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.6936
p.T61N	TCGA-F1-6177	STAD	TCGA	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.7055
p.T61N	DO38727	STAD	ICGC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.7055
p.A71T	DO222492	COCA	ICGC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation rewiring degron network	0.1667
p.A71T	DO222492	COCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation rewiring degron network	0.2222
p.K69E	DO229016	COCA	ICGC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation substituting flanking lysine	0.3333
p.K69E	DO229016	COCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation substituting flanking lysine	0.2778
p.K69E	SIDM00064	Hepatocellular Carcinoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation substituting flanking lysine	0.3333
p.K69E	SIDM00064	Hepatocellular Carcinoma	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation substituting flanking lysine	0.2778
p.K67T	DO228618	GACA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation substituting flanking lysine	0.2222
p.V75F	DO229009	LICA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.7068
p.S85I	DO50672	ORCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation rewiring degron network	0.25
p.P86L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation rewiring degron network	0.2222
p.P86L	ACH-000983	Leukemia	CCLE	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation rewiring degron network	0.2222
p.P86L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation rewiring degron network	0.2222
p.S65G	SIDM00607	Glioblastoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.6993
p.S65G	SIDM00580	Acute Myeloid Leukemia	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.6993
p.S65G	SIDM01018	Hodgkin's Lymphoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.6993
p.S65G	SIDM01463	Endometrial Carcinoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.6993
p.S65G	SIDM01559	Melanoma	GDSC	IKETPPAS	DEG_SCF_FBW7_1	58:65	Mutation altering degron motif	0.6993
p.Q77E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5633
p.Q77E	ACH-001127	Leukemia	CCLE	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5633
p.Q77E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VQQTPDGS	DEG_SCF_FBW7_1	75:82	Mutation altering degron motif	0.5633

Kaplan plot for ALAS1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALAS1

UniProt ID: P13196

Entrez ID: 211

Protein name: 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ALAS1 in