DegronMD

Uniprot ID: P13196

Source protein: 5-aminolevulinate synthase, non-specific, mitochondrial

Source gene: ALAS1

Class: DEG_SCF_FBW7_1

Location: 75:82

E3 ligase: FBXW7

DEGRON score: 0.9405

ASA_SCORE: 87.0625

COIL: 0.86

CONS_SCORE: 0.2249

DSS_SCORE: 0.8122

HELIX: 0.0964

FCONS_SCORE: 1.2033

RIG_SCORE: 0.5911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V75I	TCGA-A5-A0G1	UCEC	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	0.5965
p.V75I	DO223077	ESCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.5965
p.V75I	DO42472	UCEC	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.5965
p.D80N	TCGA-AC-A23H	BRCA	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	0.5821
p.D80N	DO2401	BRCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.5821
p.V75A	TCGA-BP-4998	KIRC	TCGA	VQQTPDGS	DEG_SCF_FBW7_1	0.6936
p.V75A	DO20210	KIRC	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.6936
p.A71T	DO222492	COCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.2222
p.K69E	DO229016	COCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.2778
p.K69E	SIDM00064	Hepatocellular Carcinoma	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	0.2778
p.K67T	DO228618	GACA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.2222
p.V75F	DO229009	LICA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.7068
p.S85I	DO50672	ORCA	ICGC	VQQTPDGS	DEG_SCF_FBW7_1	0.25
p.P86L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	0.2222
p.P86L	ACH-000983	Leukemia	CCLE	VQQTPDGS	DEG_SCF_FBW7_1	0.2222
p.P86L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VQQTPDGS	DEG_SCF_FBW7_1	0.2222
p.Q77E	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VQQTPDGS	DEG_SCF_FBW7_1	0.5633
p.Q77E	ACH-001127	Leukemia	CCLE	VQQTPDGS	DEG_SCF_FBW7_1	0.5633
p.Q77E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VQQTPDGS	DEG_SCF_FBW7_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13196	5-aminolevulinate synthase, non-specific, mitochondrial	DEG_SCF_FBW7_1	75:82	VQQTPDGS	FBXW7	0.9405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons