DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: LIG_APCC_ABBA_1

Location: 955:960

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8129

ASA_SCORE: 50.8667

COIL: 0.1975

CONS_SCORE: 0.4513

DSS_SCORE: 0.0771

HELIX: 0.0033

FCONS_SCORE: 0.8281

RIG_SCORE: 0.9678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L957I	TCGA-44-7667	LUAD	TCGA	IKLFVE	LIG_APCC_ABBA_1	0.6063
p.E968D	TCGA-91-8499	LUAD	TCGA	IKLFVE	LIG_APCC_ABBA_1	0.1111
p.S952C	TCGA-E2-A1LG	BRCA	TCGA	IKLFVE	LIG_APCC_ABBA_1	0.25
p.G948S	TCGA-EO-A22U	UCEC	TCGA	IKLFVE	LIG_APCC_ABBA_1	0.1389
p.S955C	DO4018	BRCA	ICGC	IKLFVE	LIG_APCC_ABBA_1	0.7541
p.A957S	DO228948	LICA	ICGC	IKLFVE	LIG_APCC_ABBA_1	0.7588
p.V962L	DO45031	LINC	ICGC	IKLFVE	LIG_APCC_ABBA_1	0.2778
p.L960I	DO23830	LUAD	ICGC	IKLFVE	LIG_APCC_ABBA_1	0.7174
p.G951S	DO43755	UCEC	ICGC	IKLFVE	LIG_APCC_ABBA_1	0.2222
p.E963K	SIDM00955	Melanoma	GDSC	IKLFVE	LIG_APCC_ABBA_1	0.25
p.E963K	ACH-000812	Skin Cancer	CCLE	IKLFVE	LIG_APCC_ABBA_1	0.25
p.E963K	COLO-783	skin	COSMIC	IKLFVE	LIG_APCC_ABBA_1	0.25
p.I965L	NCI-H2081	lung	COSMIC	IKLFVE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	LIG_APCC_ABBA_1	955:960	IKLFVE	APC,CDC20,FZR1	0.8129	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons