DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IKLHQE
Uniprot ID:
P18031
Source protein:
Tyrosine-protein phosphatase non-receptor type 1
Source gene:
PTPN1
Class:
LIG_APCC_ABBA_1
Location:
57:62
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9782
ASA_SCORE:
75.0167
COIL:
0.6712
CONS_SCORE:
0.5381
DSS_SCORE:
0.3799
HELIX:
0.0232
FCONS_SCORE:
0.7447
RIG_SCORE:
0.7456
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A69T
TCGA-A5-A0G2
UCEC
TCGA
IKLHQE
LIG_APCC_ABBA_1
0.1389
p.A69T
DO41235
UCEC
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.1389
p.P51L
TCGA-B5-A3FC
UCEC
TCGA
IKLHQE
LIG_APCC_ABBA_1
0.1667
p.P51L
DO41871
UCEC
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.1667
p.D48Y
TCGA-CA-6717
COAD
TCGA
IKLHQE
LIG_APCC_ABBA_1
0.0833
p.D48Y
DO8264
COAD
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.0833
p.D53H
TCGA-DK-AA77
BLCA
TCGA
IKLHQE
LIG_APCC_ABBA_1
0.2222
p.D64Y
DO228952
LICA
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.2778
p.D64Y
DO229026
LICA
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.2778
p.E57K
DO219219
LUSC
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.7022
p.I61V
DO41235
UCEC
ICGC
IKLHQE
LIG_APCC_ABBA_1
0.7076
p.A69D
SIDM01146
Gastric Carcinoma
GDSC
IKLHQE
LIG_APCC_ABBA_1
0.1389
p.A69D
ACH-000932
Gastric Cancer
CCLE
IKLHQE
LIG_APCC_ABBA_1
0.1389
p.A69D
NCI-SNU-1
stomach
COSMIC
IKLHQE
LIG_APCC_ABBA_1
0.1389
p.I57V
SIDM01133
Other Solid Cancers
GDSC
IKLHQE
LIG_APCC_ABBA_1
0.5965
p.I57V
ACH-002177
Lung Cancer
CCLE
IKLHQE
LIG_APCC_ABBA_1
0.5965
p.I57V
NCI-H835
lung
COSMIC
IKLHQE
LIG_APCC_ABBA_1
0.5965
p.P51S
SIDM00991
T-Lymphoblastic Leukemia
GDSC
IKLHQE
LIG_APCC_ABBA_1
0.1667
p.P51S
ACH-000519
Leukemia
CCLE
IKLHQE
LIG_APCC_ABBA_1
0.1667
p.P51T
ACH-001701
Head and Neck Cancer
CCLE
IKLHQE
LIG_APCC_ABBA_1
0.1667
p.K55N
NCI-H1838
lung
COSMIC
IKLHQE
LIG_APCC_ABBA_1
0.7222
Drug responses associated with PTPN1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IKLHQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P18031
Tyrosine-protein phosphatase non-receptor type 1
LIG_APCC_ABBA_1
57:62
IKLHQE
APC,CDC20,FZR1
0.9782
More...