DegronMD - P18031(PTPN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A69T	TCGA-A5-A0G2	UCEC	TCGA	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.A69T	TCGA-A5-A0G2	UCEC	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1389
p.A69T	DO41235	UCEC	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.A69T	DO41235	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1389
p.Y46H	TCGA-AA-3713	COAD	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation blocking phosphorylation signal	0.5
p.Y46H	DO8400	COAD	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation blocking phosphorylation signal	0.5
p.P51L	TCGA-B5-A3FC	UCEC	TCGA	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1667
p.P51L	TCGA-B5-A3FC	UCEC	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1944
p.P51L	DO41871	UCEC	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1667
p.P51L	DO41871	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1944
p.D48Y	TCGA-CA-6717	COAD	TCGA	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0833
p.D48Y	TCGA-CA-6717	COAD	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1111
p.D48Y	DO8264	COAD	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.0833
p.D48Y	DO8264	COAD	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1111
p.D53H	TCGA-DK-AA77	BLCA	TCGA	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.2222
p.D53H	TCGA-DK-AA77	BLCA	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.25
p.D64Y	DO228952	LICA	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.2778
p.D64Y	DO228952	LICA	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.2778
p.D64Y	DO229026	LICA	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.2778
p.D64Y	DO229026	LICA	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.2778
p.E57K	DO219219	LUSC	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.7022
p.E57K	DO219219	LUSC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation altering degron motif	0.7022
p.I61V	DO41235	UCEC	ICGC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.7076
p.I61V	DO41235	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation altering degron motif	0.7076
p.A69D	SIDM01146	Gastric Carcinoma	GDSC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.A69D	SIDM01146	Gastric Carcinoma	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1389
p.A69D	ACH-000932	Gastric Cancer	CCLE	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.A69D	ACH-000932	Gastric Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1389
p.A69D	NCI-SNU-1	stomach	COSMIC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1389
p.A69D	NCI-SNU-1	stomach	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1389
p.I57V	SIDM01133	Other Solid Cancers	GDSC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.5965
p.I57V	SIDM01133	Other Solid Cancers	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation altering degron motif	0.5965
p.I57V	ACH-002177	Lung Cancer	CCLE	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.5965
p.I57V	ACH-002177	Lung Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation altering degron motif	0.5965
p.I57V	NCI-H835	lung	COSMIC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation altering degron motif	0.5965
p.I57V	NCI-H835	lung	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation altering degron motif	0.5965
p.P51S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1667
p.P51S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1944
p.P51S	ACH-000519	Leukemia	CCLE	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1667
p.P51S	ACH-000519	Leukemia	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1944
p.P51T	ACH-001701	Head and Neck Cancer	CCLE	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation rewiring degron network	0.1667
p.P51T	ACH-001701	Head and Neck Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation rewiring degron network	0.1944
p.K55N	NCI-H1838	lung	COSMIC	IKLHQE	LIG_APCC_ABBA_1	57:62	Mutation blocking phosphorylation signal	0.7222
p.K55N	NCI-H1838	lung	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	56:62	Mutation blocking phosphorylation signal	0.75

Kaplan plot for PTPN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN1

UniProt ID: P18031

Entrez ID: 5770

Protein name: Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN1 in