DegronMD

Uniprot ID: P18031

Source protein: Tyrosine-protein phosphatase non-receptor type 1

Source gene: PTPN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 56:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.934

ASA_SCORE: 73.1

COIL: 0.642

CONS_SCORE: 0.5708

DSS_SCORE: 0.3844

HELIX: 0.0301

FCONS_SCORE: 0.7844

RIG_SCORE: 0.7442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A69T	TCGA-A5-A0G2	UCEC	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69T	DO41235	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Y46H	TCGA-AA-3713	COAD	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.5
p.Y46H	DO8400	COAD	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.5
p.P51L	TCGA-B5-A3FC	UCEC	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P51L	DO41871	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D48Y	TCGA-CA-6717	COAD	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D48Y	DO8264	COAD	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D53H	TCGA-DK-AA77	BLCA	TCGA	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.25
p.D64Y	DO228952	LICA	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D64Y	DO229026	LICA	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E57K	DO219219	LUSC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.7022
p.I61V	DO41235	UCEC	ICGC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.7076
p.A69D	SIDM01146	Gastric Carcinoma	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69D	ACH-000932	Gastric Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69D	NCI-SNU-1	stomach	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.I57V	SIDM01133	Other Solid Cancers	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I57V	ACH-002177	Lung Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.5965
p.I57V	NCI-H835	lung	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.5965
p.P51S	SIDM00991	T-Lymphoblastic Leukemia	GDSC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P51S	ACH-000519	Leukemia	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P51T	ACH-001701	Head and Neck Cancer	CCLE	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K55N	NCI-H1838	lung	COSMIC	RIKLHQE	LIG_APCC_ABBAyCdc20_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18031	Tyrosine-protein phosphatase non-receptor type 1	LIG_APCC_ABBAyCdc20_2	56:62	RIKLHQE	APC,CDC20,FZR1	0.934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons