DegronMD

Uniprot ID: Q96HP0

Source protein: Dedicator of cytokinesis protein 6

Source gene: DOCK6

Class: LIG_APCC_ABBA_1

Location: 518:523

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9413

ASA_SCORE: 79.4833

COIL: 0.9068

CONS_SCORE: 0.2581

DSS_SCORE: 0.4604

HELIX: 0.018

FCONS_SCORE: 0.9176

RIG_SCORE: 0.6983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P522L	TCGA-19-A6J5	GBM	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.6471
p.P522L	DO50114	GBM	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.6471
p.G526D	TCGA-AP-A059	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.25
p.G526D	DO41361	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.25
p.E531D	TCGA-AP-A1DV	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.1111
p.E531D	DO43186	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1111
p.D523N	TCGA-B5-A1MR	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.6932
p.D523N	DO41758	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.6932
p.S512F	TCGA-EE-A20C	SKCM	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.1667
p.S512F	DO222775	MELA	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1667
p.S512F	DO47665	SKCM	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1667
p.P513T	TCGA-EE-A29E	SKCM	TCGA	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.P513T	DO37831	SKCM	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.P513H	DO233888	GACA	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.H508N	DO229036	LICA	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.0556
p.H517R	DO220891	MELA	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.3056
p.P528H	DO229208	THCA	ICGC	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.P513A	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.P513A	ACH-000912	Lung Cancer	CCLE	IKPYPD	LIG_APCC_ABBA_1	0.1944
p.R525K	ACH-002292	Esophageal Cancer	CCLE	IKPYPD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HP0	Dedicator of cytokinesis protein 6	LIG_APCC_ABBA_1	518:523	IKPYPD	APC,CDC20,FZR1	0.9413	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons