DegronMD - Q96HP0(DOCK6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P522L	TCGA-19-A6J5	GBM	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation altering degron motif	0.6471
p.P522L	DO50114	GBM	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation altering degron motif	0.6471
p.M1195I	TCGA-AJ-A3BH	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.6507
p.M1195I	DO41638	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.6507
p.G526D	TCGA-AP-A059	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.25
p.G526D	DO41361	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.25
p.E531D	TCGA-AP-A1DV	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1111
p.E531D	DO43186	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1111
p.D523N	TCGA-B5-A1MR	UCEC	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation altering degron motif	0.6932
p.D523N	DO41758	UCEC	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation altering degron motif	0.6932
p.R1178W	TCGA-B5-A3FC	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.R1178W	DO41871	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.P1186L	TCGA-BF-AAP1	SKCM	TCGA	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.2778
p.P1186L	DO219464	SKCM	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.2778
p.I191T	TCGA-BR-4361	STAD	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.I191T	DO38887	STAD	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.E1203K	TCGA-D1-A17Q	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1389
p.E1203K	TCGA-R5-A7ZI	STAD	TCGA	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1389
p.E1203K	DO222342	STAD	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1389
p.E1203K	DO41903	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1389
p.S512F	TCGA-EE-A20C	SKCM	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1667
p.S512F	DO222775	MELA	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1667
p.S512F	DO47665	SKCM	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1667
p.P513T	TCGA-EE-A29E	SKCM	TCGA	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.P513T	DO37831	SKCM	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.R174C	TCGA-EY-A2OM	UCEC	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.R174C	DO43025	UCEC	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1944
p.D193N	TCGA-SJ-A6ZI	UCEC	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389
p.D193N	TCGA-XK-AAIW	PRAD	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389
p.D193N	DO51407	PRAD	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389
p.D193N	DO219784	UCEC	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1389
p.P513H	DO233888	GACA	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.H508N	DO229036	LICA	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.0556
p.D1199E	DO229037	LICA	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.25
p.R1191S	DO45273	LIRI	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.6316
p.H517R	DO220891	MELA	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.3056
p.G1202S	DO222843	MELA	ICGC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1667
p.S178F	DO229470	SKCA	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation blocking phosphorylation signal	0.75
p.S190I	DO229259	THCA	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2222
p.P528H	DO229208	THCA	ICGC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.R1189W	SIDM02039	Colorectal Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.8634
p.R1189W	SIDM00032	Bladder Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.8634
p.R1189W	ACH-000839	Bladder Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.8634
p.R1189W	SCaBER	urinary tract	COSMIC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation altering degron motif	0.8634
p.I1206T	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.I1206T	SIDM01494	Glioblastoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.I1206T	ACH-000333	Ovarian Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.I1206T	ACH-000445	Brain Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.I1206T	ACH-000647	Esophageal Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.I1206T	TE-1	oesophagus	COSMIC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.0556
p.S169L	SIDM00999	Bladder Carcinoma	GDSC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0556
p.S169L	639-V	urinary tract	COSMIC	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0556
p.G1204W	SIDM00153	T-Lymphoblastic Leukemia	GDSC	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1111
p.G1204W	ACH-000964	Leukemia	CCLE	QRSRLASML	DEG_APCC_DBOX_1	1188:1196	Mutation rewiring degron network	0.1111
p.P513A	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.P513A	ACH-000912	Lung Cancer	CCLE	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.1944
p.S169P	ACH-000955	Colon/Colorectal Cancer	CCLE	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0556
p.A188T	ACH-001275	Sarcoma	CCLE	PEDTPRSS	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2778
p.R525K	ACH-002292	Esophageal Cancer	CCLE	IKPYPD	LIG_APCC_ABBA_1	518:523	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOCK6

UniProt ID: Q96HP0

Entrez ID: 57572

Protein name: Dedicator of cytokinesis protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOCK6 in