DegronMD

Uniprot ID: Q96HP0

Source protein: Dedicator of cytokinesis protein 6

Source gene: DOCK6

Class: DEG_SCF_FBW7_1

Location: 179:186

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 80.9

COIL: 0.8546

CONS_SCORE: 0.3099

DSS_SCORE: 0.7198

HELIX: 0.0889

FCONS_SCORE: 1.2512

RIG_SCORE: 0.5369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I191T	TCGA-BR-4361	STAD	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	0.1944
p.I191T	DO38887	STAD	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.1944
p.R174C	TCGA-EY-A2OM	UCEC	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	0.1944
p.R174C	DO43025	UCEC	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.1944
p.D193N	TCGA-SJ-A6ZI	UCEC	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	0.1389
p.D193N	TCGA-XK-AAIW	PRAD	TCGA	PEDTPRSS	DEG_SCF_FBW7_1	0.1389
p.D193N	DO51407	PRAD	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.1389
p.D193N	DO219784	UCEC	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.1389
p.S178F	DO229470	SKCA	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.75
p.S190I	DO229259	THCA	ICGC	PEDTPRSS	DEG_SCF_FBW7_1	0.2222
p.S169L	SIDM00999	Bladder Carcinoma	GDSC	PEDTPRSS	DEG_SCF_FBW7_1	0.0556
p.S169L	639-V	urinary_tract	COSMIC	PEDTPRSS	DEG_SCF_FBW7_1	0.0556
p.S169P	ACH-000955	Colon/Colorectal Cancer	CCLE	PEDTPRSS	DEG_SCF_FBW7_1	0.0556
p.A188T	ACH-001275	Sarcoma	CCLE	PEDTPRSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HP0	Dedicator of cytokinesis protein 6	DEG_SCF_FBW7_1	179:186	PEDTPRSS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons