DegronMD

Uniprot ID: Q96HP0

Source protein: Dedicator of cytokinesis protein 6

Source gene: DOCK6

Class: DEG_APCC_DBOX_1

Location: 1188:1196

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9095

ASA_SCORE: 74.1222

COIL: 0.5898

CONS_SCORE: 0.2658

DSS_SCORE: 0.5864

HELIX: 0.2868

FCONS_SCORE: 1.0615

RIG_SCORE: 0.7

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1195I	TCGA-AJ-A3BH	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	0.6507
p.M1195I	DO41638	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.6507
p.R1178W	TCGA-B5-A3FC	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.R1178W	DO41871	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.P1186L	TCGA-BF-AAP1	SKCM	TCGA	QRSRLASML	DEG_APCC_DBOX_1	0.2778
p.P1186L	DO219464	SKCM	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.2778
p.E1203K	TCGA-D1-A17Q	UCEC	TCGA	QRSRLASML	DEG_APCC_DBOX_1	0.1389
p.E1203K	TCGA-R5-A7ZI	STAD	TCGA	QRSRLASML	DEG_APCC_DBOX_1	0.1389
p.E1203K	DO222342	STAD	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.1389
p.E1203K	DO41903	UCEC	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.1389
p.D1199E	DO229037	LICA	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.25
p.R1191S	DO45273	LIRI	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.6316
p.G1202S	DO222843	MELA	ICGC	QRSRLASML	DEG_APCC_DBOX_1	0.1667
p.R1189W	SIDM02039	Colorectal Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	0.8634
p.R1189W	SIDM00032	Bladder Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	0.8634
p.R1189W	ACH-000839	Bladder Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	0.8634
p.R1189W	SCaBER	urinary_tract	COSMIC	QRSRLASML	DEG_APCC_DBOX_1	0.8634
p.I1206T	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.I1206T	SIDM01494	Glioblastoma	GDSC	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.I1206T	ACH-000333	Ovarian Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.I1206T	ACH-000445	Brain Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.I1206T	ACH-000647	Esophageal Cancer	CCLE	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.I1206T	TE-1	oesophagus	COSMIC	QRSRLASML	DEG_APCC_DBOX_1	0.0556
p.G1204W	SIDM00153	T-Lymphoblastic Leukemia	GDSC	QRSRLASML	DEG_APCC_DBOX_1	0.1111
p.G1204W	ACH-000964	Leukemia	CCLE	QRSRLASML	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HP0	Dedicator of cytokinesis protein 6	DEG_APCC_DBOX_1	1188:1196	QRSRLASML	APC,CDC20,FZR1	0.9095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRSRLASML

Degron related mutations and impact score

Drug responses associated with DOCK6 mutations

All proteins holding degron of QRSRLASML