DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_SCF_FBW7_1

Location: 246:252

E3 ligase: FBXW7

DEGRON score: 0.9949

ASA_SCORE: 82.3714

COIL: 0.8387

CONS_SCORE: 0.3629

DSS_SCORE: 0.5239

HELIX: 0.1419

FCONS_SCORE: 0.8259

RIG_SCORE: 0.714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E244K	TCGA-36-2547	OV	TCGA	IKTPAST	DEG_SCF_FBW7_1	0.2778
p.E244K	DO30990	OV	ICGC	IKTPAST	DEG_SCF_FBW7_1	0.2778
p.P253L	TCGA-ER-A194	SKCM	TCGA	IKTPAST	DEG_SCF_FBW7_1	0.3056
p.P253L	DO47646	SKCM	ICGC	IKTPAST	DEG_SCF_FBW7_1	0.3056
p.E245K	DO233155	GACA	ICGC	IKTPAST	DEG_SCF_FBW7_1	0.3056
p.I243F	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	IKTPAST	DEG_SCF_FBW7_1	0.25
p.I243F	ACH-000353	Esophageal Cancer	CCLE	IKTPAST	DEG_SCF_FBW7_1	0.25
p.I243F	TE-15	oesophagus	COSMIC	IKTPAST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SCF_FBW7_1	246:252	IKTPAST	FBXW7	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons