DegronMD

Uniprot ID: Q9NP74

Source protein: Palmdelphin

Source gene: PALMD

Class: LIG_APCC_ABBA_1

Location: 207:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9334

ASA_SCORE: 68.55

COIL: 0.4267

CONS_SCORE: 0.896

DSS_SCORE: 0.3038

HELIX: 0.0295

FCONS_SCORE: 1.2238

RIG_SCORE: 0.8085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G206R	TCGA-73-4666	LUAD	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.3056
p.G206R	DO26230	LUAD	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.3056
p.A219V	TCGA-AA-A01R	COAD	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.1389
p.A219V	DO7934	COAD	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.1389
p.V209I	TCGA-DF-A2KU	UCEC	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.5965
p.V209I	DO223286	UCEC	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.5965
p.S221R	TCGA-E6-A1LX	UCEC	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.0833
p.S221R	DO41020	UCEC	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.0833
p.P198S	TCGA-W3-AA1R	SKCM	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.0833
p.P198S	DO51275	SKCM	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.0833
p.S216P	TCGA-XF-A9ST	BLCA	TCGA	IKVYDD	LIG_APCC_ABBA_1	0.2222
p.S216P	DO223599	BLCA	ICGC	IKVYDD	LIG_APCC_ABBA_1	0.2222
p.T205A	SIDM00217	Colorectal Carcinoma	GDSC	IKVYDD	LIG_APCC_ABBA_1	0.2778
p.T205A	ACH-000999	Colon/Colorectal Cancer	CCLE	IKVYDD	LIG_APCC_ABBA_1	0.2778
p.T205A	SNU-1040	large_intestine	COSMIC	IKVYDD	LIG_APCC_ABBA_1	0.2778
p.I222M	IST-SL1	lung	COSMIC	IKVYDD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP74	Palmdelphin	LIG_APCC_ABBA_1	207:212	IKVYDD	APC,CDC20,FZR1	0.9334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons