DegronMD - Q9NP74(PALMD)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P343L	TCGA-43-6770	LUSC	TCGA	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.2222
p.P343L	TCGA-EE-A3J7	SKCM	TCGA	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.2222
p.P343L	DO27644	LUSC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.2222
p.P343L	DO48770	SKCM	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.2222
p.G206R	TCGA-73-4666	LUAD	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.3056
p.G206R	DO26230	LUAD	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.3056
p.A219V	TCGA-AA-A01R	COAD	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1389
p.A219V	DO7934	COAD	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.1389
p.D361Y	TCGA-AP-A1E0	UCEC	TCGA	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.1111
p.D361Y	DO43154	UCEC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.1111
p.D183Y	TCGA-B5-A0JY	UCEC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1667
p.D183Y	DO43041	UCEC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1667
p.P350H	TCGA-DA-A1I7	SKCM	TCGA	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.7694
p.P350H	DO37951	SKCM	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.7694
p.V209I	TCGA-DF-A2KU	UCEC	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.5965
p.V209I	DO223286	UCEC	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation altering degron motif	0.5965
p.E167K	TCGA-DX-A6BB	SARC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.E167K	DO219996	SARC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.S221R	TCGA-E6-A1LX	UCEC	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0833
p.S221R	DO41020	UCEC	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0833
p.A175V	TCGA-EL-A3MZ	THCA	TCGA	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.5825
p.A175V	DO39505	THCA	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.5825
p.A175T	TCGA-EO-A22R	UCEC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6028
p.A175T	DO42713	UCEC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6028
p.E259Q	TCGA-G2-A3IE	BLCA	TCGA	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.E259Q	TCGA-Q1-A73O	CESC	TCGA	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.E259Q	DO767	BLCA	ICGC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.E259Q	DO51612	CESC	ICGC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.R346W	TCGA-G9-6377	PRAD	TCGA	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.3056
p.R346W	DO36348	PRAD	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.3056
p.E161K	TCGA-IR-A3LH	CESC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.E161K	DO44381	CESC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.P198S	TCGA-W3-AA1R	SKCM	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0833
p.P198S	DO51275	SKCM	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0833
p.S216P	TCGA-XF-A9ST	BLCA	TCGA	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2222
p.S216P	DO223599	BLCA	ICGC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2222
p.D361G	DO231690	LINC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.1111
p.S354L	DO220889	MELA	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.3056
p.P350L	DO220886	MELA	ICGC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.7582
p.G187E	DO222847	MELA	ICGC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0556
p.E259K	DO227531	PACA	ICGC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.T276M	SIDM01123	Prostate Carcinoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.3056
p.T276M	SIDM00266	Ewing's Sarcoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.3056
p.T276M	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.3056
p.V180F	SIDM00789	Colorectal Carcinoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.25
p.V180F	HCT-15	large intestine	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.25
p.N169H	SIDM00197	Ewing's Sarcoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6312
p.N169H	SIDM01099	Neuroblastoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6312
p.N169H	SIDM00256	Neuroblastoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6312
p.E352K	SIDM01060	Melanoma	GDSC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.591
p.E352K	ACH-000882	Skin Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.591
p.E352K	IGR-1	skin	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation altering degron motif	0.591
p.K339E	SIDM00537	Colorectal Carcinoma	GDSC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation blocking ubiquitination signal	0.5556
p.K339E	ACH-000982	Colon/Colorectal Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation blocking ubiquitination signal	0.5556
p.K339E	ACH-001345	Colon/Colorectal Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation blocking ubiquitination signal	0.5556
p.K339E	GP5d	large intestine	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation blocking ubiquitination signal	0.5556
p.E177K	SIDM00217	Colorectal Carcinoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.591
p.E177K	ACH-000999	Colon/Colorectal Cancer	CCLE	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.591
p.E177K	SNU-1040	large intestine	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.591
p.T205A	SIDM00217	Colorectal Carcinoma	GDSC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2778
p.T205A	ACH-000999	Colon/Colorectal Cancer	CCLE	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2778
p.T205A	SNU-1040	large intestine	COSMIC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.2778
p.G339A	CHP-126	autonomic ganglia	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation blocking ubiquitination signal	0.5556
p.I222M	IST-SL1	lung	COSMIC	IKVYDD	LIG_APCC_ABBA_1	207:212	Mutation rewiring degron network	0.0556
p.K259E	GP5d	large intestine	COSMIC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation rewiring degron network	0.0556
p.T186I	RPMI-2650	upper aerodigestive tract	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.0833
p.I359N	ARH-77	haematopoietic and lymphoid tissue	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	347:353	Mutation rewiring degron network	0.1667
p.E272K	IGR-1	skin	COSMIC	PTTPQRE	DEG_SCF_FBW7_2	269:275	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALMD

UniProt ID: Q9NP74

Entrez ID: 54873

Protein name: Palmdelphin (Paralemmin-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALMD in