DegronMD

Uniprot ID: Q9NP74

Source protein: Palmdelphin

Source gene: PALMD

Class: DEG_SCF_FBW7_2

Location: 269:275

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 104.9571

COIL: 0.934

CONS_SCORE: 0.5455

DSS_SCORE: 0.6507

HELIX: 0.028

FCONS_SCORE: 0.9732

RIG_SCORE: 0.7045

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E259Q	TCGA-G2-A3IE	BLCA	TCGA	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.E259Q	TCGA-Q1-A73O	CESC	TCGA	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.E259Q	DO767	BLCA	ICGC	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.E259Q	DO51612	CESC	ICGC	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.E259K	DO227531	PACA	ICGC	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.T276M	SIDM01123	Prostate Carcinoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	0.3056
p.T276M	SIDM00266	Ewing's Sarcoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	0.3056
p.T276M	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PTTPQRE	DEG_SCF_FBW7_2	0.3056
p.K259E	GP5d	large_intestine	COSMIC	PTTPQRE	DEG_SCF_FBW7_2	0.0556
p.E272K	IGR-1	skin	COSMIC	PTTPQRE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP74	Palmdelphin	DEG_SCF_FBW7_2	269:275	PTTPQRE	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons